Multiplicity in Long Noncoding RNA Biomedical Sciences
Multiplicity in Long Noncoding RNA Biomedical Sciences
复制标题
长非编码 RNA 生物医学科学的多样性
DOI：
10.11648/j.bs.20180402.11
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
K. Sasaki
中科院分区：
文献类型：
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作者：
3.R. Kurokawa;R. Komiya;T. Oyoshi;Y. Matsuno;H. Tani;M. Katahira;K. Hitachi;Y. Iwashita;T. Yamashita;K. Kondo;R. Yoneda;Y. Yamaoki;N. Ueda;T. Mashima;N. Kobayashi;T. Nagata;A. Kiyoishi;M. Miyake;F. Kano;M. Murata1;N. Hamad;K. Sasaki
本文旨在证明长链非编码RNA的复杂性或多样性。会议的报告涵盖了各种生物医学科学，以表明长链非编码RNA在每个领域的意义。会议的成果是确认了活细胞中长链非编码rna的观点。它应该是复杂的。我们将能够分析lncRNA生物作用的复杂现象，并可能解决不同生物程序中存在的规则。在植物系统中，它的长链非编码rna与哺乳动物系统相比具有独特的特性，但它告诉我们地球上所有生物背后的一个揭示的基本原理。然后，以核磁共振分析为主的结构生物学实验数据表明，核酸与RNA结合蛋白的相互作用主要集中在TLS/FUS上。通过生物化学和分子生物学对TLS进行了分析，以确定其RNA结合特异性和甲基化效应的精确数字。介绍了DNA g -四重构象的生物学意义。XIST是最著名的长链非编码RNA之一，与X染色体失活有关，与表观遗传功能冗余（如长链非编码RNA-染色质关联）的新发现有关。在iPS细胞中，它们的长链非编码RNA已被确定为化学应激反应的潜在标记物。细胞
This review article aims at demonstration of complexity or multiplicity of long noncoding RNA. The presentations of the meeting cover variety of biomedical sciences to indicate significance of long noncoding RNA in each field. The achievements of the meeting are to confirm a point of view of long noncoding RNAs in living cells. It should be in complexity. We will be able to analyze complicated phenomena of lncRNA biological actions and might have resolved the vailed rules in divergent biological programs. In the plant system, its long noncoding RNAs possesses unique property compared to mammalian systems, but tells us an unveiled fundamental principle behind all creatures in the globe. Then, experimental data from structural biology mainly by NMR analysis show that interaction of nucleic acids to RNA binding proteins focusing on TLS/FUS. Analyses of TLS are also performed by biochemistry and molecular biology to indicate precise figures of RNA binding specificity and also methylation effect on TLS. Biological meaning of the DNA local conformation like G-quadruplex is presented. XIST, one of the best known long noncoding RNA, related to X chromosome inactivation, has been linked to novel finding in epigenetic functional redundancy such as long noncoding RNA-chromatin associations. In the iPS cells, their long noncoding RNA s have been identified as a potential marker for chemical stress responses. Cellular