A simple head-mountable LED device for chronic stimulation of optogenetic molecules in freely moving mice
A simple head-mountable LED device for chronic stimulation of optogenetic molecules in freely moving mice
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DOI：
10.1016/j.neures.2011.01.007
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发表时间：
2011-05-01
影响因子：
2.9
通讯作者：
Hirase, Hajime
中科院分区：
文献类型：
--
作者：
Iwai, Youichi;Honda, Shinzou;Hirase, Hajime
我们描述了一种低成本、小型、可远程触发的LED设备，用于无线控制经颅光刺激皮质神经元，用于自由活动的小鼠。该设备可以很容易地安装在鼠标头上的高聚合物块。使用Thy1-ChR2-YFP转基因小鼠，我们证明了该设备能够在自由移动的条件下激活初级运动皮质时远程触发肌肉抽动。(C)2011年爱思唯尔爱尔兰有限公司和日本神经科学学会。版权所有。
We describe a low-cost, small, remotely triggerable LED device for wireless control of transcranial optical stimulation of cortical neurons, for use in freely moving mice. The device is easily mountable on the head of a mouse with a high-polymer block. Using the Thy1-ChR2-YFP transgenic mice, we demonstrate that the device is capable of remotely triggering muscle twitches upon activation of the primary motor cortex in freely moving conditions. (C) 2011 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.