An outbreak of foodborne illness caused by Escherichia coli O39:NM, an agent not fitting into the existing scheme for classifying diarrheogenic E-coli
An outbreak of foodborne illness caused by Escherichia coli O39:NM, an agent not fitting into the existing scheme for classifying diarrheogenic E-coli
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DOI：
10.1086/517342
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发表时间：
1997-12-01
影响因子：
6.4
通讯作者：
Tornieporth, N
中科院分区：
文献类型：
--
作者：
Hedberg, CW;Savarino, SJ;Tornieporth, N
1991年4月，一家餐馆的顾客中爆发了以产肠毒素大肠杆菌（ETEC）为临床和流行病学特征的胃肠道疾病。几组顾客的疾病特征是腹泻（100%）和痉挛（79%-88%）持续时间中位数为3-5天，中位数潜伏期为50至56小时。coli（E.大肠杆菌O39），其对热不稳定（LT）和热稳定（STa、STb）ETEC毒素呈阴性，仅从患病顾客中分离到，该微生物产生肠聚集性大肠杆菌。大肠杆菌耐热肠毒素1，并含有致病性E. coli基因位点，在培养的HEp-2细胞上不表现出对甘露糖的耐受性粘附，但在甘露糖缺乏的情况下产生粘附和消退性损伤;不属于高度特征但定义狭窄的群体的大肠杆菌可能是食源性疾病的重要原因。
An outbreak of gastrointestinal illness with clinical and epidemiologic features of enterotoxigenic Escherichia coli (ETEC) occurred among patrons of a restaurant during April 1991, Illnesses among several groups of patrons were characterized by diarrhea (100%) and cramps (79%-88%) lasting a median of 3-5 days, Median incubation periods ranged from 50 to 56 h, A nonmotile strain of E. coli (E. coli O39), which was negative for heat-labile (LT) and heat-stable (STa, STb) ETEC toxins, was isolated only from ill patrons, This organism produced enteroaggregative E. coli heat-stable enterotoxin 1 and contained the enteropathogenic E. coli gene locus for enterocyte effacement; it did not display mannose-resistant adherence, but produced attaching and effacing lesions in the absence of mannose on cultured HEp-2 cells, E. coli that are not part of highly characterized but narrowly defined groups may be important causes of foodborne illness.