Racial/ethnic disparities in sleep-disordered breathing during pregnancy in the nuMoM2b study.
Racial/ethnic disparities in sleep-disordered breathing during pregnancy in the nuMoM2b study.
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nuMoM2b 研究中怀孕期间睡眠呼吸障碍的种族/民族差异。
DOI：
10.1002/oby.23697
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Alcantara,Carmela
中科院分区：
文献类型：
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作者：
Lucchini,Maristella;Rayport,Yael;Valeri,Linda;Jelic,Sanja;St-Onge,Marie-Pierre;O'Brien,LouiseM;Alcantara,Carmela
本研究的目的是评估3702名6岁至15岁和22岁至31 孕周的孕妇睡眠呼吸障碍的患病率和严重程度，检查体重指数是否改变了种族/民族与睡眠呼吸障碍的关系，以及减肥干预措施是否可以减少睡眠呼吸障碍的种族/民族差异。结果本研究包括61.2%的非西班牙裔白人(NHW)、11.9%的非西班牙裔黑人(NHB)、18.5%的西班牙裔和3.7%的亚洲人。在6~15 周，亚洲孕妇的SDB患病率高于NHW孕妇(优势比[OR]1.81，95%CI[1.07，2.97])，而在21~32 周，亚洲孕妇的SDB患病率高于NHW孕妇(OR 2.2，95%CI[1.1，4.0])。早孕不同种族/民族SDB的严重程度不同，NHB孕妇的呼吸暂停低通气指数(AHI)比NHW高(OR 1.35，95%CI[1.07，1.69])。超重/肥胖与更高的呼吸暂停低密度脂蛋白指数相关(β=2.36，95%CI[1.97，2.84])。控制的直接影响分析表明，在怀孕早期，NHB和西班牙裔孕妇的AHI比正常体重的NHW孕妇要低。结论本研究将关于SDB的种族/民族差异的知识推广到怀孕人群。
ObjectiveThe aim of this study was to assess the prevalence and severity of sleep‐disordered breathing (SDB) across racial/ethnic groups in 3702 pregnant people at 6 to 15 and 22 to 31 weeks gestational age, examine whether BMI modifies the association between race/ethnicity and SDB, and investigate whether interventions to reduce weight might reduce racial/ethnic disparities in SDB.MethodsDifferences by race/ethnicity in SDB prevalence and severity were quantified via linear, logistic, or quasi‐Poisson regression. Controlled direct effect was used to estimate whether intervening on BMI would remove/diminish differences by race/ethnicity in SDB severity.ResultsThis study comprised 61.2% non‐Hispanic White (nHW), 11.9% non‐Hispanic Black (nHB), 18.5% Hispanic, and 3.7% Asian people. SDB prevalence was higher for nHB compared with nHW pregnant people at 6 to 15 weeks (odds ratio [OR] 1.81, 95% CI [1.07, 2.97]), whereas at 21 to 32 weeks, Asian pregnant people had a higher SDB prevalence than nHW (OR 2.2, 95% CI [1.1, 4.0]). The severity of SDB differed across racial/ethnic groups in early pregnancy, with nHB pregnant people having a higher apnea‐hypopnea index (AHI) (OR 1.35, 95% CI [1.07, 1.69]) compared with nHW. Having overweight/obesity was associated with a higher AHI (β = 2.36, 95% CI [1.97, 2.84]). Controlled direct effect analyses indicated that in early pregnancy, nHB and Hispanic pregnant people would have a lower AHI compared with nHW people had they had normal weight.ConclusionsThis study extends knowledge on racial/ethnic disparities in SDB to a pregnant population.