No impact of treated hyperprolactinemia on cumulative live birth rate and perinatal outcomes in in vitro fertilization-embryo transfer
No impact of treated hyperprolactinemia on cumulative live birth rate and perinatal outcomes in in vitro fertilization-embryo transfer
复制标题
治疗高催乳素血症对体外受精-胚胎移植中的累积活产率和围产期结局没有影响
DOI：
10.1111/jog.13957
复制
发表时间：
2019-07-01
影响因子：
1.6
通讯作者：
Xu, Yanwen
中科院分区：
文献类型：
--
作者：
Duan, Yuwei;Liu, Xinyan;Xu, Yanwen
目的探讨高催乳素血症治疗对体外受精/卵胞浆内单精子注射胚胎移植(IVF/ICSI-ET)妊娠结局的影响。方法对2012年1月至2016年12月接受IVF/ICSI-ET治疗的123例高催乳素血症患者(病例组)和369例对照组进行回顾性队列研究。治疗后仍有高催乳素血症者43例，均为异常组。以取卵1个周期后的累计活产率(CLBR)为主要结局。使用Fine和Gray检验的事件发生时间分析来比较病例组和对照组之间的CLBR。结果病例组治疗前催乳素中位数为80.00 ng/m L，治疗后下降至14.80 ng/m L，与对照组(15.17 ng/m L)相近(P=0.316)。病例组和对照组之间在基线特征上没有发现显著差异。病例组1个周期取卵成功率为69.1%，对照组为66.4%(P=0.580)。病例组与对照组围产儿结局无显著差异。异常组的妊娠结局和围产儿结局与病例组和对照组相似。结论IVF-ET治疗高催乳素血症对CLBR及围产儿结局的影响不明显。
Aim To investigate whether treated hyperprolactinemia has an impact on pregnancy outcomes in in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET). Methods A retrospective cohort study was conducted on 535 women who underwent IVF/ICSI-ET between January 2012 and December 2016, of which 123 had treated hyperprolactinemia (case group), 369 were matched controls. Besides, 43 remained hyperprolactinemic after treatment consisted of abnormal group. Cumulative live birth rate (CLBR) after one oocyte retrieval cycle was taken as the primary outcome. A time-to-event analysis using Fine and Gray's test was used to compare CLBR between case and control groups. Results The median prolactin level was 80.00 ng/mL before dopamine agonist treatment in case group, and it reduced to 14.80 ng/mL after the treatment, similar to the level of control group (15.17 ng/mL, P = 0.316). No significant differences in baseline characteristics were found between case and control groups. The CLBR after one oocyte retrieval cycle were 69.1% (85/123) and 66.4% (245/369) in the case group and control group, respectively (P = 0.580). No significant differences were found between case and control groups in perinatal outcomes. Pregnancy and perinatal outcomes of abnormal group were similar to those of case and control groups. Conclusion Impact of treated hyperprolactinemia on CLBR and perinatal outcomes in IVF-ET was not evident.