High triglyceride to high-density lipoprotein cholesterol ratio and arterial stiffness in postmenopausal Korean women
High triglyceride to high-density lipoprotein cholesterol ratio and arterial stiffness in postmenopausal Korean women
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DOI：
10.1111/jch.13484
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发表时间：
2019-03-01
影响因子：
2.8
通讯作者：
Lee, Yong-Jae
中科院分区：
文献类型：
--
作者：
Chung, Tae-Ha;Shim, Jae-Yong;Lee, Yong-Jae
甘油三酯与高密度脂蛋白胆固醇（TG/HDL）的比率与胰岛素抵抗呈正相关，并且它已成为心血管疾病的独立预测因子。更年期的特点是各种有害的代谢和血管变化，这些变化可能导致甘油三酯升高、高密度脂蛋白胆固醇降低和动脉僵硬度。多项流行病学研究表明，高 TG/HDL 比值与成人和青少年人群的动脉僵硬度呈正相关。目前尚不清楚 TG/HDL 比值是否与绝经后妇女的臂踝 PWV (baPWV) 有关。因此，作者旨在研究 TG/HDL 比值与 434 名绝经后女性通过 baPWV 测量的动脉僵硬度之间的关联。使用多元逻辑回归分析调整 TG/HDL 比率四分位数的混杂变量后，计算高 baPWV 的比值比 (OR) 和 95% 置信区间 (95% CI)。有意义的心脏代谢变量的平均值随着 TG/HDL 比率四分位数的增加而增加。调整后的 baPWV (SE) 随 TG/HDL 四分位数显着增加：调整年龄、体重指数 (BMI) 和收缩压后，Q1 = 1412 (22.1)、Q2 = 1469 (21.4)、Q3 = 1482 (21.0) 和 Q4 = 1505 (21.6) cm/s。调整年龄、BMI、吸烟状况、定期运动、平均动脉压、空腹血糖、总胆固醇水平、高血压、对数转换 C 反应蛋白以及抗高血压和降脂药物的使用后，高 PWV 的最高 TG/HDL 比率四分位数与最低 TG/HDL 比率四分位数的 OR (95% CI) 为 2.77 (1.16-6.63)。 TG/HDL 比值与绝经后韩国女性的动脉僵硬度呈正相关且独立相关。
The ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL) is positively linked to insulin resistance, and it has emerged as an independent predictor of cardiovascular disease. Menopause is characterized by various detrimental metabolic and vascular changes that may lead to high TG with low HDL cholesterol and arterial stiffness. Several epidemiological studies have reported that high TG/HDL ratio has a positive association with arterial stiffness in both adult and adolescent populations; it is not known whether TG/HDL ratio is related to brachial-ankle PWV (baPWV) in postmenopausal women. Thus, the authors aimed to investigate the association between TG/HDL ratio and arterial stiffness as measured by baPWV in 434 postmenopausal women. The odds ratios (ORs) and 95% confidence intervals (95% CIs) for high baPWV were calculated after adjusting for confounding variables across TG/HDL ratio quartiles using multiple logistic regression analysis. The mean values of meaningful cardiometabolic variables increased with TG/HDL ratio quartiles. The adjusted baPWV (SEs) significantly increased with TG/HDL quartiles: Q1 = 1412 (22.1), Q2 = 1469 (21.4), Q3 = 1482 (21.0), and Q4 = 1505 (21.6) cm/s after adjusting for age, body mass index (BMI), and systolic blood pressure. The OR (95% CI) of the highest TG/HDL ratio quartile as compared to the lowest TG/HDL ratio quartile for high PWV was 2.77 (1.16-6.63) after adjusting for age, BMI, smoking status, regular exercise, mean arterial pressure, fasting plasma glucose, total cholesterol level, hypertension, log-transformed C-reactive protein, and the use of antihypertensive and lipid-lowering drugs. The TG/HDL ratio was positively and independently associated with arterial stiffness in postmenopausal Korean women.