Progress against laryngeal cancer in The Netherlands between 1989 and 2010
Progress against laryngeal cancer in The Netherlands between 1989 and 2010
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DOI：
10.1002/ijc.28388
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发表时间：
2014-02-01
影响因子：
6.4
通讯作者：
de Vries, Esther
中科院分区：
文献类型：
--
作者：
van Dijk, Boukje A. C.;Karim-Kos, Henrike E.;de Vries, Esther
喉癌在荷兰是一种多发的头颈部癌症。主要危险因素是吸烟和过度饮酒。我们研究的目的是通过研究荷兰的发病率、死亡率和存活率的趋势来评估抗喉癌的进展。所有在1989年至2010年期间在荷兰癌症登记处被诊断为喉部浸润性原发鳞状细胞癌的患者都被纳入分析。描述了整个组的发病率、死亡率、治疗和存活率的时间趋势，并按性别和亚组进行分层：声门、声门上和声门下。男性最常受影响的部位是声门(69%)，女性最常受影响的部位是声门上(55%)。声门癌的诊断比声门上癌的分期要低。男性的发病率和死亡率分别下降了2.5%和2.8%，但女性的发病率和死亡率保持稳定，除了老年女性的死亡率上升(EAPC：+2.5%)。声门型(85%)和声门上型(50%)癌症患者的五年相对生存率稳定，而高分期癌症患者更多地接受放射治疗。多变量分析显示，女性、年轻患者死亡的相对额外风险较低(
Cancer of the larynx is a frequently occurring head and neck cancer in The Netherlands. The main risk factors are smoking and excessive alcohol consumption. The aim of our study was to evaluate the progress against laryngeal cancer by studying trends in incidence, mortality and survival in The Netherlands. All patients in The Netherlands Cancer Registry diagnosed with invasive primary squamous cell carcinoma of the larynx during the period 1989-2010 were included for analysis. Time trends in incidence, mortality, treatment and survival were described for the total group and stratified by sex and subsite: glottis, supraglottis and subglottis. The most frequently affected subsite for men was the glottis (69%) and for women the supraglottis (55%). Glottic cancer was diagnosed at lower stages than supraglottic cancer. Incidence and mortality rates decreased for males with -2.5 and -2.8% per year, respectively, but remained stable for women, except for an increasing mortality rate in older women (EAPC: +2.5%). Five-year relative survival rates were stable for glottic (85%) and supraglottic (50%) cancer, whereas patients with high-staged cancers more often received radiotherapy. Multivariable analysis showed lower relative excess risks of dying for women, younger patients (