Mulberry leaf extract intake reduces hyperglycaemia in streptozotocin (STZ)-induced diabetic rats fed high-fat diet
Mulberry leaf extract intake reduces hyperglycaemia in streptozotocin (STZ)-induced diabetic rats fed high-fat diet
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DOI：
10.1016/j.jff.2014.02.018
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发表时间：
2014-05-01
影响因子：
5.6
通讯作者：
Buchowski, Maciej S.
中科院分区：
文献类型：
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作者：
Jeszka-Skowron, Magdalena;Flaczyk, Ewa;Buchowski, Maciej S.
研究桑叶提取物对高脂饮食糖尿病大鼠的抗氧化活性和抗糖尿病作用。高脂饮食4周后，Wistar大鼠注射链脲佐菌素诱导非肥胖型2型糖尿病。确诊糖尿病后，在高脂日粮中添加桑叶干、桑叶乙醇或丙酮提取物4周。桑乙醇提取物中酚类物质绿原酸和黄酮醇苷含量较高，在降低血糖、提高胰岛素水平和抗氧化活性指标方面优于丙酮提取物或干叶提取物。研究结果证实了桑葚及其活性成分在stz诱导的非肥胖糖尿病大鼠模型中通过纠正高血糖、增加胰岛素分泌和改善抗氧化状态来调节糖代谢的关键机制。桑叶的抗糖尿病作用可能与提取工艺有关。(C) 2014 Elsevier Ltd.版权所有。
This study evaluated the antioxidant activity and anti-diabetic effect of mulberry (Morus alba L. wielkolistna zolwinska) leaf extracts in diabetic rats fed a high-fat diet. After initial 4-week high-fat diet, streptozotocin was injected in Wistar rats to induce non-obese type 2 diabetes. After confirmation of diabetes, animals were treated with mulberry dried leaves, leaf-derived ethanol or acetone extracts added to high-fat diet for 4 weeks. Mulberry ethanol extract with higher level of phenolics - chlorogenic acid and flavonol glucosides was more effective than acetone extract or dry leaves in the lowering of blood glucose, increasing insulin level and markers of antioxidant activity. The results confirm key mechanisms related to the effect of mulberry and its bioactive components on modulation of glucose metabolism through correcting hyperglycaemia, increasing insulin secretion, and improving antioxidant status in STZ-induced non-obese diabetic rat model. Antidiabetic effects exerted by mulberry leaves might depend on the extraction process. (C) 2014 Elsevier Ltd. All rights reserved.