Mitochondrial DNA analysis of Northwest African populations reveals genetic exchanges with European, Near-Eastern, and sub-Saharan populations
Mitochondrial DNA analysis of Northwest African populations reveals genetic exchanges with European, Near-Eastern, and sub-Saharan populations
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DOI：
10.1046/j.1469-1809.1998.6260531.x
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发表时间：
1998-11-01
影响因子：
1.9
通讯作者：
Bandelt, HJ
中科院分区：
文献类型：
--
作者：
Rando, JC;Pinto, F;Bandelt, HJ
遗传学研究强调了北非和撒哈拉以南非洲人群之间的对比，但北非mtDNA库与欧洲，近东和撒哈拉以南非洲的mtDNA库的特殊亲和力以前没有被调查过。我分析了268个来自不同西北非洲人群的mtDNA控制区序列，包括几个塞内加尔群体，并将其与mtDNA数据库进行了比较。我们已经确定了一些线粒体基序，这些基序具有地理特异性，可能早于北非和西非现代语系的分布和多样化。先前在阿尔及利亚柏柏尔人中发现的高频率的细胞线粒体DNA基序（16172C，16219G）在西北非洲显然是无所不在的，可能反映了超过20000年的区域连续性。柏柏尔人的大多数母系祖先必须来自欧洲和近东，因为新石器时代。相反，尼日利亚人和西撒哈拉人与撒哈拉以南非洲人的线粒体DNA有很大的亲和力，但不占主导地位。
Genetic studies have emphasized the contrast between North Africas and sub-Saharan populations, but the particular affinities of the North African mtDNA pool to that of Europe, the Near East, and sub-Saharan Africa have not previously been investigated. me have analysed 268 mtDNA control-region sequences from various Northwest African populations including several Senegalese groups and compared these with the mtDNA database. We have identified a few mitochondrial motifs that are geographically specific and likely predate the distribution and diversification of modern language families in North and West Africa. A cel tain mtDNA motif (16172C, 16219G), previously found in Algerian Berbers at high frequency, is apparently omnipresent in Northwest Africa and may reflect regional continuity of more than 20 000 years. The majority of the maternal ancestors of the Berbers must have come from Europe and the Near East since the Neolithic. The Mauritanians and West-Saharans, in contrast; bear substantial though not dominant mtDNA affinity with sub-Saharans.