Development of tendon structure and function: regulation of collagen fibrillogenesis.
Development of tendon structure and function: regulation of collagen fibrillogenesis.
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DOI：
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发表时间：
2005-03
影响因子：
1.9
通讯作者：
Gao Zhang;B. Young;Y. Ezura;Y. Ezura;Michele Favata;L. Soslowsky;S. Chakravarti;D. Birk
中科院分区：
文献类型：
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作者：
Gao Zhang;B. Young;Y. Ezura;Y. Ezura;Michele Favata;L. Soslowsky;S. Chakravarti;D. Birk
在肌腱中，成熟的力学性能的发展依赖于肌腱特异性细胞外基质的组装。这种基质由肌腱成纤维细胞合成，并由组织为纤维的胶原原纤维以及原纤维相关的胶原蛋白和非胶原蛋白组成。所有这些成分在发育和生长过程中整合在一起，形成一个功能组织。在肌腱发育过程中，胶原原纤维形成和基质组装通过多个步骤进行，其中每个步骤独立调节，最终形成结构和功能成熟的组织。胶原原纤维形成发生在一系列细胞外区室中，其中原纤维中间体被组装，并且成熟原纤维通过中间体的沉积后融合过程生长。在未成熟的原纤维中间体被并入纤维中之后，发生线性和侧向原纤维生长。这一过程受细胞外大分子与纤维相互作用的调控。与数量上较小的纤维胶原、纤维相关胶原和蛋白聚糖的相互作用影响纤维形成中的不同步骤，并且细胞外微区为肌腱成纤维细胞提供了调节这些细胞外相互作用的机制。
In the tendon, the development of mature mechanical properties is dependent on the assembly of a tendon-specific extracellular matrix. This matrix is synthesized by the tendon fibroblasts and composed of collagen fibrils organized as fibers, as well as fibril-associated collagenous and non-collagenous proteins. All of these components are integrated, during development and growth, to form a functional tissue. During tendon development, collagen fibrillogenesis and matrix assembly progress through multiple steps where each step is regulated independently, culminating in a structurally and functionally mature tissue. Collagen fibrillogenesis occurs in a series of extracellular compartments where fibril intermediates are assembled and mature fibrils grow through a process of post-depositional fusion of the intermediates. Linear and lateral fibril growth occurs after the immature fibril intermediates are incorporated into fibers. The processes are regulated by interactions of extracellular macromolecules with the fibrils. Interactions with quantitatively minor fibrillar collagens, fibril-associated collagens and proteoglycans influence different steps in fibrillogenesis and the extracellular microdomains provide a mechanism for the tendon fibroblasts to regulate these extracellular interactions.