Movement-related correlates of single-cell activity in the medial mammillary nucleus of the rat during a pellet-chasing task.
Movement-related correlates of single-cell activity in the medial mammillary nucleus of the rat during a pellet-chasing task.
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DOI：
10.1152/jn.00194.2005
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发表时间：
2005-09
影响因子：
2.5
通讯作者：
P. E. Sharp;Shawnda Turner-Williams
中科院分区：
文献类型：
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作者：
P. E. Sharp;Shawnda Turner-Williams
尽管乳头体的功能作用仍然不清楚，但病变研究表明该结构可能在记忆中发挥作用，特别是对空间信息的记忆。事实上，在解剖学上，乳头体与边缘系统区域紧密相连，例如海马结构，这也被认为在空间行为中发挥作用。迄今为止研究的每个边缘区域都包含细胞，这些细胞可以发出动物在太空中旅行时的瞬时位置和/或方向的信号。事实上，外侧乳头体核本身就含有头部方向细胞，并且被认为对于该方向信号的初始计算至关重要。在这里，我们提供了一个初步的报告，在乳头体内侧核的细胞活动。当大鼠执行一个追逐小球的任务时，细胞被记录下来，这个任务已经被用于研究位置和头部方向细胞的大部分工作。主要发现是：1）大约1/3的细胞显示出与头部角运动的时间精确关系，因此它们区别地指示顺时针和逆时针角运动，2）大约60%的细胞显示出与平移运动的时间粗略相关，3）几乎所有细胞的放电率在θ频率下都受到强烈调制，和4）没有细胞显示定向或位置相关活动的证据。这些数据表明，内侧和外侧乳头核一起提供方向和轨迹信息，被认为是在海马区的空间信号的产生至关重要。
Although the functional role of the mammillary bodies has remained obscure, lesion studies suggest this structure may play a role in memory-in particular, memory for spatial information. Indeed, anatomically, the mammillary bodies are strongly interconnected with limbic system regions, such as the hipppocampal formation, which are also thought to play a role in spatial behavior. Each of these limbic regions so far investigated contains cells that signal either the momentary location and/or directional heading of an animal as it travels through space. In fact, the lateral mammillary nucleus itself contains head direction cells, and is thought to be critical for the initial calculation of this directional signal. Here, we provide an initial report on cell activity in the medial mammillary nucleus. Cells were recorded while rats performed a pellet-chasing task that has been used for much of the work on place and head direction cells. The main findings are 1) approximately 1/3 of the cells showed a temporally precise relationship to angular motion of the head, so that they differentially indicated clockwise versus counterclockwise angular motion, 2) approximately 60% of the cells showed a temporally coarse correlation with translational motion, 3) firing rate for almost all cells was strongly modulated at theta frequency, and 4) no cells showed evidence of either directional or place-related activity. These data suggest that the medial and lateral mammillary nuclei together provide the directional and trajectory information thought to be critical for generation of the spatial signals in the hippocampal region.