HLA class II associations in African-American female patients with Graves' disease.
HLA class II associations in African-American female patients with Graves' disease.
复制标题
患有格雷夫斯病的非裔美国女性患者的 HLA II 类关联。
DOI：
10.1089/thy.1996.6.37
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
DeGroot,LJ
中科院分区：
文献类型：
--
作者：
Yanagawa,T;DeGroot,LJ
Graves病（GD）是一种自身免疫性甲状腺疾病。疾病表型的发展被认为取决于环境因素和几个基因协同或独立群体的作用。人类白细胞抗原（HLA）复合物的基因或与其密切相关的基因在决定不同种族人群中GD的遗传易感性方面是重要的。我们之前报道过，在所有非裔美国GD患者中未检测到明显的HLA I类或-DR关联。为了进一步研究GD与HLA II类等位基因的关系，我们使用序列特异性寡核苷酸探针分析聚合酶链反应扩增的DNA，对52名非裔美国女性GD患者和55名对照进行HLA- drb1、-DQA1和-DQB1分型。患者与对照组HLA分布无明显差异。这些发现表明，HLA-DR和DQ区域对非裔美国妇女GD易感性的贡献很小。
Graves' disease (GD) is an autoimmune thyroid disease. Development of the disease phenotype is believed to be dependent on environmental factors and the action of several genes either in concert or in independent groups. Genes of, or closely associated to, the human leukocyte antigen (HLA) complex are important in determining genetic predisposition to GD in various ethnic groups. We previously reported that no significant HLA class I or -DR associations were detected in the total group of African-American patients with GD. To further investigate the associations of GD with HLA class II alleles, 52 unrelated African-American female patients with GD and 55 controls were typed for HLA-DRB1, -DQA1, and -DQB1, using sequence-specific oligonucleotide probes to analyze polymerase chain reaction amplified DNA. There were no significant differences in HLA distribution between patients and controls. These findings indicate that the contribution of HLA-DR and DQ regions to susceptibility to GD is small in African-American women.