Prognostic value of p53 expression and histopathological parameters in squamous cell carcinoma of oral tongue
Prognostic value of p53 expression and histopathological parameters in squamous cell carcinoma of oral tongue
复制标题
DOI：
10.1017/s0022215100144184
复制
发表时间：
1999-05-01
影响因子：
1.7
通讯作者：
Hosal, AS
中科院分区：
文献类型：
--
作者：
Ünal, OF;Ayhan, A;Hosal, AS
TNM分期系统有帮助，但不足以确定口腔舌鳞癌患者的预后。单独的t期不能预测隐匿性淋巴结转移。本文对70例口腔舌鳞癌患者进行了回顾性的组织病理学检查。观察组织学分化、肿瘤厚度、神经和淋巴血管间隙浸润情况、淋巴细胞浸润量及肿瘤浸润方式。采用免疫组化检查检测p53的免疫反应性。采用卡方检验分析这些组织病理学参数和p53免疫反应性对淋巴结转移和局部复发的影响。在淋巴结转移方面，两组之间唯一具有统计学意义的差异是肿瘤厚度，分别为9mm (p
The TNM staging system is helpful but not enough to determine prognosis of the patients with squamous cell carcinoma of the oral tongue. T-stage alone is not suggestive for prediction of occult nodal metastases. For this reason, histopathological examination of 70 patients with squamous cell carcinoma of the oral tongue was done retrospectively. The histological differentiation, tumour thickness, perineural and lymphovascular space invasions, the amount of lymphocyte infiltration and pattern of tumour invasion were examined. Immunohistochemical examination was used to determine p53 immunoreactivity as well. The effect of these histopathological parameters and p53 immunoreactivity on nodal metastases and locoregional recurrence were analyzed using the chi-squared test. In terms of nodal metastases the only statistically significant difference between the two groups was tumour thickness, either 9 mm (p