EEG coherence of prefrontal areas in normal and schizophrenic males during perceptual activation.
EEG coherence of prefrontal areas in normal and schizophrenic males during perceptual activation.
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正常和精神分裂症男性在知觉激活过程中前额叶区域的脑电图一致性。
DOI：
10.1176/jnp.3.2.169
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Guich,SM
中科院分区：
文献类型：
--
作者：
Hoffman,RE;Buchsbaum,MS;Escobar,MD;Makuch,RW;Nuechterlein,KH;Guich,SM
多项研究表明，精神分裂症患者存在前额叶功能障碍。前额叶皮质的功能不是孤立的，而是依赖于与其他大脑区域的广泛联系。通过计算13例未服药男性精神分裂症患者和9名正常男性受试者不同头皮脑电(EEG)信号的相关性来评估皮质区域之间的功能关系。精神分裂症患者与额叶前区相关的阿尔法频段一致性与正常对照组相比，当受试者处于认知状态时大致相同，但在前一组中，当进行退化刺激连续操作测试时，某些电极对的阿尔法频段一致性降低。这些发现中的大多数并不是由于阿尔法能量的变化所解释的，这表明精神分裂症患者延伸到前额叶以外的“皮质回路”可能受到干扰。
Multiple studies have demonstrated prefrontal dysfunction among schizophrenics. The prefrontal cortex does not function in isolation, but instead relies on extensive connections with other brain areas. Functional relationships between cortical areas were assessed by calculating the coherences between different scalp electroencephalogram (EEG) signals recorded from 13 unmedicated male patients with schizophrenia and 9 normal male subjects. Alpha-band coherences linked to prefrontal areas in schizophrenic patients were about the same as those of normal controls when subjects were cognitively“at rest,” but they were reduced for certain electrode pairs in the former group when performing the degraded-stimulus con tinuous performance test. Most of these findings were not accounted for by changes in alpha power, suggesting that “cortical circuits” extending beyond prefrontal areas may be disrupted in schizophrenia.