Strain-specific white-spotting patterns in laboratory mice.
Strain-specific white-spotting patterns in laboratory mice.
复制标题
实验室小鼠品系特异性白斑模式。
DOI：
10.1111/j.1600-0749.1999.tb00522.x
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Lamoreux,ML
中科院分区：
文献类型：
--
作者：
Lamoreux,ML
White spotting is the absence of melanocytes (pigment cells) from part or all of the locations in the body where they are normally found. At least in the case of theW (kit)locus, white spotting has been attributed to apoptosis. In addition to the death of melanoblasts, white spotting might result from their failure to migrate to their normal locations. These developmental failures are known to be melanocyte‐specific in some instances and environment‐specific in others. The environment is defined as the tissues surrounding the melanoblast. Patterns of white spotting were examined on mice mutant atthe piebald(s),patch (Ph), dominant spotting (WJ2) rumpwhite (Rw)orbelted (bt)loci. Thedominant spottinglocus has been cloned and found to encode KIT; it has been suggested thatPatchencodes the linked alpha‐PDGF receptor.Piebaldencodes the endothelin beta receptor. In each case, the phenotypes expressed when the allele was backcrossed onto one inbred strain C57BL/6 (B6), were compared with phenotypes expressed when the allele was backcrossed onto a different inbred strain, JU/CtLm (JU). The literature documents genetic loci that influence the extent of the white spotted area; we herein demonstrate that genetic loci also influence the location where the white spot (absence of melanocytes) will occur over the body of the mouse. Spotting occurs in a more anterior direction on JU mice that arepiebald, patchordominant‐spottedcompared with similar B6 mice. The relationship is reversed inrumpwhitemice, where white spotting is more anterior in the C57BL/6 mice than in the JU mice. The spotting pattern ofbeltedmice was not modified by the background genome. Thus, the Mendelian observations indicate that several loci, which differ in JU compared with B6 mice, influence the size and the location of white spots on the mouse.
