Biogenesis of transport intermediates in the endocytic pathway
Biogenesis of transport intermediates in the endocytic pathway
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DOI：
10.1016/s0014-5793(99)00561-x
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发表时间：
1999-06-04
期刊：
影响因子：
3.5
通讯作者：
Gruenberg, J
中科院分区：
文献类型：
--
作者：
Gu, F;Gruenberg, J
越来越多的证据表明，细胞器之间的膜交通可以通过不同类型的中间体来实现。小的（< 100 nm）和短寿命的囊泡介导从质膜或trans-Golgi网络到内体的转运，并且这些囊泡的形成取决于特定的衔接子复合物。相反，从早期到晚期内体的转运是通过相对大的（类似于0.5 μ m）、长寿命和多囊泡的中间体实现的，并且它们的生物发生取决于内体COP-I蛋白。在这里，我们回顾最近的工作，这些不同的运输中间体的形成，我们讨论，特别是，外壳蛋白，货物分子中包含的分选信号和脂质在囊泡生物发生中的新兴作用，（C）1999年欧洲生物化学学会联合会。
Evidence is accumulating that membrane traffic between organelles can be achieved by different types of intermediates. Small (< 100 nm) and short-lived vesicles mediate transport from the plasma membrane or the trans-Golgi network to endosomes, and formation of these vesicles depends on specific adapter complexes, In contrast, transport from early to late endosomes is achieved by relatively large (similar to 0.5 mu m), long-lived and multivesicular intermediates, and their biogenesis depends on endosomal COP-I proteins. Here, we review recent work on the formation of these different transport intermediates, and we discuss, in particular, coat proteins, sorting signals contained in cargo molecules and the emerging role of lipid in vesicle biogenesis, (C) 1999 Federation of European Biochemical Societies.