High Mobility Group Box-1 Protein and Interleukin 33 Expression in Allergic Rhinitis
High Mobility Group Box-1 Protein and Interleukin 33 Expression in Allergic Rhinitis
复制标题
过敏性鼻炎中高迁移率族 Box-1 蛋白和白细胞介素 33 的表达
DOI：
10.1159/000519575
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Jian Zhang
中科院分区：
文献类型：
--
作者：
Nongping Zhong;Qing Luo;Xiaoyan Huang;Jieqing Yu;Jing Ye;Jian Zhang
背景：变应性鼻炎(AR)以炎症反应为特征。高迁移率族蛋白1(HMGB1)和白介素33(IL-33)是损伤相关的分子模式分子，具有许多类似于促炎细胞因子的特征。然而，IL-33和HMGB1在AR中的作用尚不清楚。本研究旨在探讨HMGB1和IL-33在AR中的作用。方法：20例变应性鼻炎患者(AR组)和10例正常对照组(正常对照组)。免疫组织化学方法检测HMGB1和IL-33在下鼻甲粘膜上皮细胞中的表达。然后，体外培养人鼻粘膜上皮细胞(HNECs)，用屋尘螨变应原(DerP1)刺激细胞。采用实时定量聚合酶链式反应和酶联免疫吸附试验检测HNECs中HMGB1和IL-33的表达。结果：变应性鼻炎组鼻粘膜中HMGB1和IL-33的表达均高于正常组，差异有统计学意义(P
Background: Allergic rhinitis (AR) is characterized by an inflammatory reaction. High mobility group box 1 (HMGB1) protein and interleukin (IL)-33 are damage-associated molecular pattern molecules and have many characteristics similar to pro-inflammatory cytokines. However, the role of IL-33 and HMGB1 in AR remains unclear. The aim of this study is to explore the role of HMGB1 and IL-33 in AR. Methods: Twenty patients with AR (AR group) and 10 normal controls (normal group) were enrolled in this study. HMGB1 and IL-33 expression were analyzed by immunohistochemistry in epithelial cells of the inferior turbinate mucosa samples. Then, the human nasal mucosa epithelial cells (HNECs) were cultured in vitro, and the house dust mite allergen (Derp1) was used to stimulate the cells. Quantitative real-time PCR and ELISA assay were performed to detect HMGB1 and IL-33 expression in HNECs. Results: The expression of HMGB1 and IL-33 in the nasal mucosa was higher in the AR group than in the normal group, with a statistically significant difference (p
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影响因子：
3.8
作者：
Xuewei Zhu;Jianan Cong;Ben Yang;Yuxin Sun
通讯作者：
Xuewei Zhu;Jianan Cong;Ben Yang;Yuxin Sun
影响因子：
3
作者：
Cavone L;Cuppari C;Manti S;Grasso L;Arrigo T;Calamai L;Salpietro C;Chiarugi A
通讯作者：
Chiarugi A
影响因子：
5
作者：
M. Suzukawa;R. Koketsu;M. Iikura;S. Nakae;Kenji Matsumoto;H. Nagase;H. Saito;K. Matsushima;K. Ohta;Kazuhiko Yamamoto;M. Yamaguchi
通讯作者：
M. Suzukawa;R. Koketsu;M. Iikura;S. Nakae;Kenji Matsumoto;H. Nagase;H. Saito;K. Matsushima;K. Ohta;Kazuhiko Yamamoto;M. Yamaguchi
影响因子：
5
作者：
Iikura, Motoyasu;Suto, Hajime;Nakae, Susumu
通讯作者：
Nakae, Susumu
DOI：
--
发表时间：
2012
期刊：
--
影响因子：
--
作者：
C. Cuppari;A. Salpietro;L. Grasso;S. Manti;C. Salpietro
通讯作者：
C. Cuppari;A. Salpietro;L. Grasso;S. Manti;C. Salpietro