Enhanced optical imaging of human gliomas and tumor margins
Enhanced optical imaging of human gliomas and tumor margins
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DOI：
10.1097/00006123-199602000-00015
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发表时间：
1996-02-01
期刊：
影响因子：
4.8
通讯作者：
Hochman, DW
中科院分区：
文献类型：
--
作者：
Haglund, MM;Berger, MS;Hochman, DW
影响颅内神经胶质瘤患者总体生存率和生活质量的潜在变量之一是肿瘤切除的范围，从而使残留病灶体积最小。涉及人类神经胶质瘤增强光学成像的技术有可能定位肿瘤、识别切除边缘剩余的肿瘤并确定肿瘤的分级。在一项涉及 9 名接受内源性脑肿瘤切除手术的患者的初步研究中，使用吲哚菁绿作为静脉内对比增强剂进行了增强光学成像。在注射吲哚菁绿之前和之后获得光学图像。对九名患者的研究表明，正常大脑、低级别星形细胞瘤和恶性星形细胞瘤之间的动态光信号存在差异。恶性肿瘤切除边缘的光学成像显示邻近正常组织和剩余肿瘤组织之间的差异。使用对比度增强染料吲哚菁绿对人类神经胶质瘤进行增强光学成像，提供了一种区分皮质表面和切除边缘深处的正常大脑和肿瘤组织的潜在方法。能够在手术室获取实时信息和反馈可以使神经外科医生最大限度地切除肿瘤，同时保留正常大脑并提高术中活检的诊断准确性。当肿瘤在中枢神经系统之外的部位被切除时，增强的光学成像可能会提高手术的准确性和安全性。
ONE OF THE potential variables affecting the overall survival and quality of life of patients with intracranial gliomas is the extent of tumor resection that results in the smallest volume of residual disease. A technique involving enhanced optical imaging of human gliomas has the potential to localize tumors, identify tumor remaining at the resection margins, and determine the grade of the tumor. In a preliminary study involving nine patients undergoing surgery for the removal of intrinsic brain tumors, enhanced optical imaging was performed using indocyanine green as an intravenous contrast-enhancement agent. Optical images were obtained before and after injection of the indocyanine green. The studies in the nine patients showed differences in the dynamic optical signals among normal brain, low-grade astrocytomas, and malignant astrocytomas. Optical imaging of the resection margins in malignant tumors showed differences between adjacent normal tissue and remaining tumor tissue. Enhanced optical imaging of human gliomas using a contrast-enhancing dye, indocyanine green, provides a potential means to differentiate between normal brain and tumor tissue at the cortical surface and in the depths of the resection margins. Having the ability to obtain real-time information and feedback in the operating room may allow neurosurgeons to maximize the extent of tumor resection while sparing normal brain and increasing the diagnostic accuracy of intraoperative biopsies. Enhanced optical imaging potentially could facilitate the accuracy and safety of surgery when tumors are removed at sites even outside the central nervous system.