Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis.
Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis.
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DOI：
10.1038/nri.2016.100
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发表时间：
2016-11
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影响因子：
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通讯作者：
Cadwell K
中科院分区：
文献类型：
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作者：
Cadwell K
自噬的细胞降解过程参与免疫的多个方面，包括细胞自主防御、先天免疫信号传导和抗原呈递。自噬和炎症信号级联之间的广泛串扰确保了对病原体的强大免疫应答，同时避免对宿主的附带损害。一些慢性炎症性疾病与自噬功能障碍有关。诱导自噬的途径，如模式识别受体的下游途径，反过来也受到自噬的调节。自噬可以以上下文依赖的方式增加和减少相同炎症信号级联的不同组分。保守的自噬蛋白的许多免疫相关功能反映了自噬机制的非经典功能，代表了治疗干预的新机会。本文的在线版本（doi：10.1038/nri.2016.100）包含补充材料，可供授权用户使用。本文对自噬在免疫中的一般功能、自噬与免疫信号通路之间的相互作用以及自噬-免疫串扰在多细胞免疫应答和疾病中的作用进行了全面概述。本文的在线版本（doi：10.1038/nri.2016.100）包含补充材料，可供授权用户使用。自噬在免疫中具有广泛的功能，从细胞自主防御到协调复杂的多细胞免疫应答。成功解决感染和避免自身免疫需要自噬和感知免疫环境的途径之间的有效和及时的沟通。近年来的研究表明，多种免疫介质可诱导或抑制自噬。越来越清楚的是，免疫信号级联受到自噬的调节，并且在强大的免疫应答之后恢复稳态严重依赖于该途径。重要的是，自噬在介导免疫中的非典型形式的例子是普遍的。本文就自噬与炎症信号通路之间相互作用机制的研究进展作一综述。对自噬机制的更好理解为治疗感染性和炎症性疾病提供了希望。本文的在线版本（doi：10.1038/nri.2016.100）包含补充材料，可供授权用户使用。
The cellular degradative process of autophagy participates in multiple aspects of immunity, including cell-autonomous defence, innate immune signalling and antigen presentation. Extensive crosstalk between autophagy and inflammatory signalling cascades ensures a robust immune response towards pathogens while avoiding collateral damage to the host. Several chronic inflammatory disorders are associated with autophagy dysfunction. Pathways that induce autophagy, such as those downstream of pattern recognition receptors, are conversely subject to regulation by autophagy. Autophagy can increase and decrease different components of the same inflammatory signalling cascade in a context-dependent manner. Many immune-related functions of conserved autophagy proteins reflect non-canonical functions of the autophagy machinery, representing new opportunities for therapeutic intervention. The online version of this article (doi:10.1038/nri.2016.100) contains supplementary material, which is available to authorized users. This article provides a comprehensive overview of the general functions of autophagy in immunity, the interactions between autophagy and immune signalling pathways and the role of autophagy–immune crosstalk in multicellular immune responses and disease. The online version of this article (doi:10.1038/nri.2016.100) contains supplementary material, which is available to authorized users. Autophagy has broad functions in immunity, ranging from cell-autonomous defence to coordination of complex multicellular immune responses. The successful resolution of infection and avoidance of autoimmunity necessitates efficient and timely communication between autophagy and pathways that sense the immune environment. The recent literature indicates that a variety of immune mediators induce or repress autophagy. It is also becoming increasingly clear that immune signalling cascades are subject to regulation by autophagy, and that a return to homeostasis following a robust immune response is critically dependent on this pathway. Importantly, examples of non-canonical forms of autophagy in mediating immunity are pervasive. In this article, the progress in elucidating mechanisms of crosstalk between autophagy and inflammatory signalling cascades is reviewed. Improved mechanistic understanding of the autophagy machinery offers hope for treating infectious and inflammatory diseases. The online version of this article (doi:10.1038/nri.2016.100) contains supplementary material, which is available to authorized users.