Studies on the mechanism of protein-induced hypercalciuria in older men and women.
Studies on the mechanism of protein-induced hypercalciuria in older men and women.
复制标题
老年男性和女性蛋白质诱发高钙尿症机制的研究。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
H. Linkswiler
中科院分区：
文献类型：
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作者：
Sally A. Schuette;MichaelB Zemel;H. Linkswiler
通过人体代谢研究，观察蛋白质摄入水平对老年人尿钙、钙吸收和钙平衡的影响，进一步探讨蛋白质引起高钙尿症的机制。蛋白质摄入量从47克增加到112克，同时保持钙、镁和磷的摄入量不变，导致尿钙增加，钙潴留减少。肾小球滤过率增加，肾小管重吸收分数减少蛋白质摄入量的增加，总的肾脏酸，铵和硫酸盐排泄量增加了一倍以上，而尿钠减少了38%。尿钙的变化与肾总酸和硫酸盐排泄量的增加以及肾小管钙重吸收分数的减少呈正相关。因此，数据表明，蛋白质诱导的高钙尿症是由于肾小球滤过率的增加和肾小管钙重吸收分数的减少，后者可能是由肾小管细胞上的酸负荷增加引起的。
A human metabolic study was conducted to observe the effect of level of protein intake on urinary calcium, calcium absorption and calcium balance in older adults and to further study the mechanisms of protein-induced hypercalciuria. An increase in protein intake from about 47 to 112 g while maintaining calcium, magnesium and phosphorus intakes constant caused an increase in urinary calcium and a decrease in calcium retention. Glomerular filtration rate was increased and fractional renal tubular reabsorption was decreased by the increase in protein intake; total renal acid, ammonium and sulfate excretions more than doubled, whereas urinary sodium decreased by 38%. The changes in urinary calcium were positively correlated with the increase in total renal acid and sulfate excretion as well as with the decrease in fractional renal tubular reabsorption of calcium. Thus, the data indicate that protein-induced hypercalciuria is due to an increase in glomerular filtration rate and a decrease in fractional renal tubular reabsorption of calcium, the latter of which may be caused by the increased acid load on the renal tubular cells.