Production of inner ear fluids.
Production of inner ear fluids.
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DOI：
10.1152/physrev.1988.68.4.1083
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发表时间：
1988-10
影响因子：
33.6
通讯作者：
Olivier Sterkers;E. Ferrary;C. Amiel
中科院分区：
文献类型：
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作者：
Olivier Sterkers;E. Ferrary;C. Amiel
内耳液、内淋巴和。外淋巴对听力和平衡是必不可少的。除了将机械刺激传递到耳蜗器官和前庭器官外，它们还直接参与感觉器官中发生的机械-电传导过程。事实上，内耳感觉细胞在其顶端纤毛表面沐浴着内淋巴，在其底部突触表面沐浴着外淋巴，一种液体被另一种液体取代会改变从感觉细胞记录到的受体电位。这两种液体在组成上有很大的不同：内淋巴是钾盐的正极化溶液，而外淋巴的化学成分类似于血浆超滤液，但从几个角度来看，它与超滤液不同。内淋巴和外淋巴的研究提出了三个主要困难。1)由于内耳液位于骨块的深处，获取内耳液变得困难。2)内淋巴和外淋巴的体积分别在纳升和微升范围内，这意味着使用了超微量分析技术。3)它们是
The inner ear fluids, endolymph and. perilymph, are essential to hearing and equilibration. Beyond their role in the transmission of mechanical stimuli to the cochlear and vestibular organs, they are directly concerned in the mechanoelectrical transduction processes that take place in the sensory organs. Indeed, the inner ear sensory cells are bathed with endolymph at their apical ciliated surfaces and with perilymph at their basal synaptic ones, and the replacement of one fluid by the other alters the receptor potentials that are recorded from the sensory cells. The two fluids differ dramatically in composition: endolymph is a positively polarized solution of potassium salts, whereas perilymph has a chemical composition resembling that of a plasma ultrafiltrate, from which it differs, however, from several points of view. The study of endolymph and perilymph raises three main difficulties. 1) Access to the inner ear fluids is made difficult by their deep location in a bony massif. 2) Their volumes are in the nanoliter and microliter ranges for endolymph and perilymph, respectively, which implies the use of ultramicroanalysis techniques. 3) They are