Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5-6years: findings from the ABCD multi-ethnic birth cohort
Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5-6years: findings from the ABCD multi-ethnic birth cohort
复制标题
DOI：
10.1111/1471-0528.13574
复制
发表时间：
2016-02-01
影响因子：
5.8
通讯作者：
Painter, R. C.
中科院分区：
文献类型：
--
作者：
Krikke, G. G.;Grooten, I. J.;Painter, R. C.
目的探讨妊娠早期母体维生素B-12和叶酸水平是否与5-6岁子代心脏代谢危险因素相关。设计前瞻性多民族出生队列，阿姆斯特丹出生儿童及其发展研究（ABCD）。2003年至2004年期间，研究人员联系了居住在阿姆斯特丹的12373名孕妇参与研究。人口可获得母亲在妊娠早期维生素B-12或叶酸状况和5-6岁健康状况信息的母子对（n=1950）。方法测定孕妇妊娠早期（中位妊娠13周）摄入时血清中维生素B-12和叶酸的浓度。在对5-6岁儿童进行健康检查时收集了人体测量、血压和空腹血液样本。采用多元线性回归来研究母亲血清浓度与儿童结局之间的关系，校正混杂因素。主要结果测量：出生时的胎龄、出生体重、体重指数（BMI）、血糖水平、甘油三酯水平、5-6岁时的血压和心率。结果妊娠早期母体叶酸水平较低与子代BMI略高相关[每10单位降低0.07kg/m(2)， 95%可信区间（CI） 0.01, 0.13]。母体维生素B-12浓度低与较高的心率相关（每100单位降低：0.49次/分钟，95% CI 0.11, 0.87）。结论本研究为妊娠早期母体营养可能影响子代心脏代谢健康提供了进一步的证据。孕期叶酸和维生素B-12水平低与后代较高的身体质量指数和心率有关。怀孕期间叶酸和维生素B-12水平低与后代较高的身体质量指数和心率有关。
ObjectiveTo explore whether maternal vitamin B-12 and folate status during early pregnancy are associated with cardiometabolic risk factors in the offspring at age 5-6.DesignProspective multi-ethnic birth cohort, the Amsterdam Born Children and their Development study (ABCD).Setting12373 pregnant women living in Amsterdam were approached between 2003 and 2004 for participation in the study.PopulationMother-child pairs for whom information on maternal vitamin B-12 or folate status in early gestation and health at age 5-6years was available (n=1950).MethodsVitamin B-12 and folate concentrations were determined in maternal serum at intake in early pregnancy (median 13weeks' gestation). Anthropometric measurements, blood pressure and fasting blood samples were collected during a health check of children aged 5-6years. Multiple linear regression was performed to investigate the association between maternal serum concentrations and children's outcomes, corrected for confounders.Main outcome measuresGestational age at birth, birthweight, body mass index (BMI), glucose levels, triglyceride levels, blood pressure and heart rate of the offspring at age 5-6.ResultsLow maternal folate levels during early pregnancy were associated with slightly higher BMI in the offspring [decrease per 10 units: 0.07kg/m(2), 95% confidence interval (CI) 0.01, 0.13]. Low maternal vitamin B-12 concentrations were associated with higher heart rates (decrease per 100 units: 0.49 beats/min, 95% CI 0.11, 0.87).ConclusionThis study provides further evidence that maternal nutrition in early pregnancy may possibly program cardiometabolic health of the offspring.Tweetable abstractLow folate and vitamin B-12 levels during pregnancy are associated with higher BMI and heart rate in offspring.Tweetable abstract Low folate and vitamin B-12 levels during pregnancy are associated with higher BMI and heart rate in offspring.