Diurnal rhythm and concordance between objective and subjective hot flashes: the Hilo Women's Health Study
Diurnal rhythm and concordance between objective and subjective hot flashes: the Hilo Women's Health Study
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DOI：
10.1097/gme.0b013e3181cbb3c6
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发表时间：
2010-05-01
影响因子：
2.7
通讯作者：
Brown, Daniel E.
中科院分区：
文献类型：
--
作者：
Sievert, Lynnette L.;Reza, Angela;Brown, Daniel E.
目的：研究湿热环境中多民族人群潮热的昼夜变化规律，并采用动态和实验室测量方法检测潮热主客观指标的符合率。方法：受试者年龄为45~55岁。女性佩戴Biolog潮热监测仪(UFI，加利福尼亚州莫罗湾)，24小时记日记，还参加了3小时的实验室测量(n=199)。昼夜节律用多项式回归进行评估。对于每个女性来说，客观记录的潮热符合主观经验，被视为真阳性读数。主观潮热被认为是计算假阳性和假阴性读数的标准。结果：胸骨、颈部和主观潮热的频率在1500+/-1小时达到峰值，不同种族之间没有差异。实验室结果支持在动态监测中看到的模式。胸骨和颈项监测显示，真阳性测量的频率相同，但非胸骨电极检测到更多的假阳性读数。实验室监测显示，假阴性的频率非常低。在真阳性或假阳性测量的频率上没有种族差异。欧洲血统的女性更容易报告没有客观证明的潮热(假阴性测量)。结论：希洛湿热环境中潮热的昼夜模式和高峰与更温和环境的结果相似。胸骨测量与非胸骨测量以及各种族的真阳性测量之间缺乏差异，这表明出汗模式的人口差异没有明显的影响。
Objective: The aims of this study were to test for a diurnal pattern in hot flashes in a multiethnic population living in a hot, humid environment and to examine the rates of concordance between objective and subjective measures of hot flashes using ambulatory and laboratory measures.Methods: Study participants aged 45 to 55 years were recruited from the general population of Hilo, HI. Women wore a Biolog hot flash monitor (UFI, Morro Bay, CA), kept a diary for 24 hours, and also participated in 3-hour laboratory measures (n = 199). Diurnal patterns were assessed using polynomial regression. For each woman, objectively recorded hot flashes that matched subjective experience were treated as true-positive readings. Subjective hot flashes were considered the standard for computing false-positive and false-negative readings. True-positive, false-positive, and false-negative readings were compared across ethnic groups by chi(2) analyses.Results: Frequencies of sternal, nuchal, and subjective hot flashes peaked at 1500 +/- 1 hours with no difference by ethnicity. Laboratory results supported the pattern seen in ambulatory monitoring. Sternal and nuchal monitoring showed the same frequency of true-positive measures, but nonsternal electrodes picked up more false-positive readings. Laboratory monitoring showed very low frequencies of false negatives. There were no ethnic differences in the frequency of true-positive or false-positive measures. Women of European descent were more likely to report hot flashes that were not objectively demonstrated (false-negative measures).Conclusions: The diurnal pattern and peak in hot flash occurrence in the hot humid environment of Hilo were similar to results from more temperate environments. Lack of variation in sternal versus nonsternal measures and in true-positive measures across ethnicities suggests no appreciable effect of population variation in sweating patterns.