Function and Regulation of the Endosomal Fusion and Fission Machineries
Function and Regulation of the Endosomal Fusion and Fission Machineries
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DOI：
10.1101/cshperspect.a016832
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发表时间：
2014-03-01
影响因子：
7.2
通讯作者：
Ungermann, Christian
中科院分区：
文献类型：
--
作者：
Gautreau, Alexis;Oguievetskaia, Ksenia;Ungermann, Christian
内膜系统内的细胞器通过囊泡通量连接。沿着内吞途径，内体是最通用的细胞器之一。它们通过管状突起对货物进行分类以进行回收，或通过腔内囊泡进行降解。分选涉及许多机器，它们介导内体运输中间体的裂变以及与其他内体或最终与溶酶体的融合。在这里，我们回顾了我们对这些过程的理解的最新进展，特别关注 Rab GTPases、束缚因子和逆转录酶。细胞骨架最近也被认为是内体膜动力学的核心参与者，这篇综述涵盖了通过与货物回收和内体裂变相关的 WASH 和 Arp2/3 复合物控制分支肌动蛋白网络形成的机制。
Organelles within the endomembrane system are connected via vesicle flux. Along the endocytic pathway, endosomes are among the most versatile organelles. They sort cargo through tubular protrusions for recycling or through intraluminal vesicles for degradation. Sorting involves numerous machineries, which mediate fission of endosomal transport intermediates and fusion with other endosomes or eventually with lysosomes. Here we review the recent advances in our understanding of these processes with a particular focus on the Rab GTPases, tethering factors, and retromer. The cytoskeleton has also been recently recognized as a central player in membrane dynamics of endosomes, and this review covers the regulation of the machineries that govern the formation of branched actin networks through the WASH and Arp2/3 complexes in relation with cargo recycling and endosomal fission.