Transcriptional landscape of PTEN loss in primary prostate cancer.
Transcriptional landscape of PTEN loss in primary prostate cancer.
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DOI：
10.1186/s12885-021-08593-y
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发表时间：
2021-07-26
期刊：
影响因子：
3.8
通讯作者：
Marchionni L
中科院分区：
文献类型：
--
作者：
Imada EL;Sanchez DF;Dinalankara W;Vidotto T;Ebot EM;Tyekucheva S;Franco GR;Mucci LA;Loda M;Schaeffer EM;Lotan T;Marchionni L
PTEN is the most frequently lost tumor suppressor in primary prostate cancer (PCa) and its loss is associated with aggressive disease. However, the transcriptional changes associated with PTEN loss in PCa have not been described in detail. In this study, we highlight the transcriptional changes associated with PTEN loss in PCa. Using a meta-analysis approach, we leveraged two large PCa cohorts with experimentally validated PTEN and ERG status by Immunohistochemistry (IHC), to derive a transcriptomic signature of PTEN loss, while also accounting for potential confounders due to ERG rearrangements. This signature was expanded to lncRNAs using the TCGA quantifications from the FC-R2 expression atlas. The signatures indicate a strong activation of both innate and adaptive immune systems upon PTEN loss, as well as an expected activation of cell-cycle genes. Moreover, we made use of our recently developed FC-R2 expression atlas to expand this signature to include many non-coding RNAs recently annotated by the FANTOM consortium. Highlighting potential novel lncRNAs associated with PTEN loss and PCa progression. We created a PCa specific signature of the transcriptional landscape of PTEN loss that comprises both the coding and an extensive non-coding counterpart, highlighting potential new players in PCa progression. We also show that contrary to what is observed in other cancers, PTEN loss in PCa leads to increased activation of the immune system. These findings can help the development of new biomarkers and help guide therapy choices. The online version contains supplementary material available at 10.1186/s12885-021-08593-y.
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影响因子：
30.8
作者：
Carver, Brett S.;Tran, Jennifer;Gopalan, Anuradha;Chen, Zhenbang;Shaikh, Safa;Carracedo, Arkaitz;Alimonti, Andrea;Nardella, Caterina;Varmeh, Shohreh;Scardino, Peter T.;Cordon-Cardo, Carlos;Gerald, William;Pandolfi, Pier Paolo
通讯作者：
Pandolfi, Pier Paolo
影响因子：
64.5
作者：
Cancer Genome Atlas Research Network
通讯作者：
Cancer Genome Atlas Research Network
影响因子：
3.8
作者：
Cicek, MS;Liu, X;Witte, JS
通讯作者：
Witte, JS
DOI：
10.1038/s41379-018-0083-x
发表时间：
2018-10
期刊：
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
影响因子：
--
作者：
Kaur HB;Guedes LB;Lu J;Maldonado L;Reitz L;Barber JR;De Marzo AM;Tosoian JJ;Tomlins SA;Schaeffer EM;Joshu CE;Sfanos KS;Lotan TL
通讯作者：
Lotan TL
影响因子：
50.3
作者：
Carver BS;Chapinski C;Wongvipat J;Hieronymus H;Chen Y;Chandarlapaty S;Arora VK;Le C;Koutcher J;Scher H;Scardino PT;Rosen N;Sawyers CL
通讯作者：
Sawyers CL