Gene-expression analysis and the basal-like breast cancer subtype.
Gene-expression analysis and the basal-like breast cancer subtype.
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DOI：
10.2217/14796694.3.1.55
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发表时间：
2007-02-01
期刊：
影响因子：
--
通讯作者：
Carey, Lisa A
中科院分区：
文献类型：
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作者：
Finnegan, Timothy J;Carey, Lisa A
对乳腺癌基因表达模式的分析表明，它不是一个单一的实体，而是由几个具有特征性分子谱的生物学上不同的亚型组成。这些分子特征证实了雌激素受体（ER）阴性与ER阳性不同的临床印象，并通过鉴定乳腺癌亚型（包括ER阴性亚群中的基底样和人表皮生长因子受体（HER）2/ER亚型以及ER阳性疾病中的管腔A和B亚型）扩展了我们的理解。基底样亚型的特征在于ER相关和HER 2相关基因组的低表达水平，因此在这些蛋白质的临床测定中通常为“三阴性”。这篇综述讨论了乳腺癌的分子特征，重点是基底样亚型的临床特征和治疗方案。
Analysis of the patterns of gene expression in breast cancer suggests that it is not a single entity, but is comprised of several biologically distinct subtypes with characteristic molecular profiles. These molecular profiles confirm the clinical impression that estrogen receptor (ER)-negative differs from ER-positive, and expands our understanding by identifying breast cancer subtypes, including the basal-like and human epidermal growth factor receptor (HER)2/ER subtypes within the ER-negative subset, and the luminal A and B subtypes within ER-positive disease. The basal-like subtype is characterized by the low expression levels of the ER-related and the HER2-related group of genes, and therefore is often 'triple negative' on clinical assays for these proteins. This review discusses the molecular profiles of breast cancer with a focus on the clinical characteristics of, and treatment options for, the basal-like subtype.