Intestinal mucosal atrophy and adaptation
Intestinal mucosal atrophy and adaptation
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DOI：
10.3748/wjg.v18.i44.6357
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发表时间：
2012-11-28
影响因子：
4.3
通讯作者：
Basson, Marc D.
中科院分区：
文献类型：
--
作者：
Shaw, Darcy;Gohil, Kartik;Basson, Marc D.
粘液适应是肠道内环境稳定的重要过程。肠粘膜适应一系列病理条件，包括饥饿、短肠综合征、肥胖和减肥手术。广义上，这些适应性功能可以分为增殖和分化。这些都是由不同的相互作用与激素，免疫，饮食，神经和机械刺激的影响。似乎可以通过操纵适应的生理学来改善临床结果。本综述将总结当前对适应性基础科学的理解，描述广泛的治疗干预的潜在靶点，并讨论如何将其纳入整体治疗计划。更深入地了解适应的生理基础将确定进一步的干预目标，以改善临床结果。(C)2012年百世登。All rights reserved.
Mucosal adaptation is an essential process in gut homeostasis. The intestinal mucosa adapts to a range of pathological conditions including starvation, short-gut syndrome, obesity, and bariatric surgery. Broadly, these adaptive functions can be grouped into proliferation and differentiation. These are influenced by diverse interactions with hormonal, immune, dietary, nervous, and mechanical stimuli. It seems likely that clinical outcomes can be improved by manipulating the physiology of adaptation. This review will summarize current understanding of the basic science surrounding adaptation, delineate the wide range of potential targets for therapeutic intervention, and discuss how these might be incorporated into an overall treatment plan. Deeper insight into the physiologic basis of adaptation will identify further targets for intervention to improve clinical outcomes. (C) 2012 Baishideng. All rights reserved.