Evidence for a Frontoparietal Control System Revealed by Intrinsic Functional Connectivity
Evidence for a Frontoparietal Control System Revealed by Intrinsic Functional Connectivity
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DOI：
10.1152/jn.90355.2008
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发表时间：
2008-12-01
影响因子：
2.5
通讯作者：
Buckner, Randy L.
中科院分区：
文献类型：
--
作者：
Vincent, Justin L.;Kahn, Itamar;Buckner, Randy L.
Vincent JL, Kahn I, Snyder AZ, Raichle ME, Buckner RL。内在功能连接揭示了额顶叶控制系统的证据。中国生物医学工程学报（英文版）首次发表于2008年9月17日；doi: 10.1152 / jn.90355.2008。最近发现了两种功能不同且可能相互竞争的大脑网络，它们在对外部世界的关注和涉及长期记忆的内部定向心理方面的不同作用，可以大致区分开来。这两个网络的核心是背侧注意系统和海马体-皮质记忆系统，这是大脑默认网络的一个组成部分。本研究在三个独立的功能性磁共振成像数据集（n = 105）中使用自发血氧水平依赖（BOLD）信号相关性来定义第三个系统，即额顶叶控制系统，该系统在空间上介于这两个先前定义的系统之间。额顶叶控制系统包括许多支持认知控制和决策过程的区域，包括外侧前额叶皮层、前扣带皮层和顶叶下小叶。对额叶和顶叶皮层的详细分析，包括使用高分辨率数据，揭示了连续但不同的区域的明确证据：一般来说，与额叶顶叶控制系统相关的区域位于背侧注意和海马皮层记忆系统的组成部分之间。因此，额顶叶控制系统在解剖学上定位于整合来自这两个对立的大脑系统的信息。
Vincent JL, Kahn I, Snyder AZ, Raichle ME, Buckner RL. Evidence for a frontoparietal control system revealed by intrinsic functional connectivity. J Neurophysiol 100: 3328-3342, 2008. First published September 17, 2008; doi: 10.1152/jn.90355.2008. Two functionally distinct, and potentially competing, brain networks have been recently identified that can be broadly distinguished by their contrasting roles in attention to the external world versus internally directed mentation involving long-term memory. At the core of these two networks are the dorsal attention system and the hippocampal-cortical memory system, a component of the brain's default network. Here spontaneous blood-oxygenation-level-dependent ( BOLD) signal correlations were used in three separate functional magnetic resonance imaging data sets ( n = 105) to define a third system, the frontoparietal control system, which is spatially interposed between these two previously defined systems. The frontoparietal control system includes many regions identified as supporting cognitive control and decision-making processes including lateral prefrontal cortex, anterior cingulate cortex, and inferior parietal lobule. Detailed analysis of frontal and parietal cortex, including use of high-resolution data, revealed clear evidence for contiguous but distinct regions: in general, the regions associated with the frontoparietal control system are situated between components of the dorsal attention and hippocampal-cortical memory systems. The frontoparietal control system is therefore anatomically positioned to integrate information from these two opposing brain systems.