Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses
Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses
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DOI：
10.4049/jimmunol.168.4.1528
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发表时间：
2002-02-15
影响因子：
4.4
通讯作者：
Shen, H
中科院分区：
文献类型：
--
作者：
Foulds, KE;Zenewicz, LA;Shen, H
在本研究中，我们比较了李斯特菌感染后 Ag 特异性 CD4 和 CD8 T 细胞的增殖和分化。我们的结果表明，CD4 T 细胞对感染做出反应，分裂次数有限，后代在分裂早期表现出增殖停滞。即使感染剂量增加，CD4 T 细胞也表现出这种受限的增殖模式，并且不会被驱动进行广泛的克隆扩增。这与 CD8 T 细胞形成鲜明对比，CD8 T 细胞因感染而发生广泛增殖。当 CD4 和 CD8 T 细胞在体外接受一致的抗 CD3 刺激时，这些差异也很明显。总之，这些结果表明 CD4 和 CD8 T 细胞被编程为分别进行有限和广泛的增殖，以适应它们作为调节细胞和效应细胞的功能。
In this study, we compared the proliferation and differentiation of Ag-specific CD4 and CD8 T cells following Listeria infection. Our results show that CD4 T cells responding to infection divide a limited number of times, with progeny exhibiting proliferative arrest in early divisions. Even with increased infectious doses, CD4 T cells display this restricted proliferative pattern and are not driven to undergo extensive clonal expansion. This is in striking contrast to CD8 T cells, which undergo extensive proliferation in response to infection. These differences are also evident when CD4 and CD8 T cells receive uniform anti-CD3 stimulation in vitro. Together, these results suggest that CD4 and CD8 T cells are programmed to undergo limited and extensive proliferation, respectively, to suit their function as regulator and effector cells.