Association between the pancreas transplantation and survival of patients with diabetes: A single center experience.
Association between the pancreas transplantation and survival of patients with diabetes: A single center experience.
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DOI：
10.1371/journal.pone.0186827
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Han DJ
中科院分区：
文献类型：
--
作者：
Choi JY;Jung JH;Shin S;Kim YH;Han DJ
胰腺移植被认为是复杂糖尿病患者的一种治疗选择。在这项研究中，我们比较了等待单独胰腺移植(PTA)、同时进行胰腺-肾移植(SPK)和肾移植后胰腺(PAK)的患者和移植受者的存活率。对本中心2000年2月至2015年12月收治的503例PTA患者(PTA：116例；SPK：303例；PAK：84例)和280例PT患者(PTA：89例；SPK：155例；PAK：36例)进行了回顾性分析，其中11.9%(60/503)的患者和4.3%(12/280)的PT患者死亡。等待名单组第一年的总存活率较高(99.3%比97.8%)，此后PT组的总存活率明显高于等待名单组(p=0.039)。与等待名单上的患者相比，移植受者全因死亡的总体相对风险PTA为2.145(P=0.285)，PAK为0.688(P=0.735)，SPK为0.361(P=0.012)。SPK移植受者有相当高的生存收益，尽管等待时间相对较长，特别是在一年后。此外，PTA和PAK也可以被认为是一种治疗选择，因为患者的生存并不差。
Pancreas transplantation is considered a therapeutic option for patients with complicated diabetes mellitus. In this study, we compared survival rate between patients on the waiting list for pancreas transplant alone(PTA), simultaneous pancreas–kidney(SPK) transplant, and pancreas after kidney(PAK) transplant and transplant recipients. A total of 503 patients (PTA:n = 116; SPK:n = 303; PAK:n = 84) and 280 PT recipients (PTA:n = 89; SPK:n = 155; PAK:n = 36) were retrospectively analyzed at our center between February 2000 and December 2015; 11.9%(60/503) of the patients on the waiting list and 4.3%(12/280) of the PT recipients died. The overall survival rate was higher in the waiting list group for the first year (99.3% vs. 97.8%), after which it was significantly higher in PT group (p = 0.039). The overall relative risk of all-cause mortality for transplant recipients was 2.145(p = 0.285) for PTA, 0.688(p = 0.735) for PAK, however,0.361 (p = 0.012) for SPK compared with that for the waiting list patients. SPK transplant recipients had considerable higher survival benefits, despite the relatively long waiting period, especially after 1 year. In addition, PTA and PAK can also be considered as a treatment option as patient survival was not poor.
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