Diversity study of 12 X-chromosomal STR loci in Hui ethnic from China
Diversity study of 12 X-chromosomal STR loci in Hui ethnic from China
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中国回族12个X染色体STR位点多样性研究
DOI：
10.1002/elps.201400045
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发表时间：
2014-07-01
期刊：
影响因子：
2.9
通讯作者：
Wei, Xing
中科院分区：
文献类型：
--
作者：
Meng, Hao-Tian;Han, Jun-Tao;Wei, Xing
近年来，X染色体短串联重复序列（X-STR）作为常染色体STR应用的补充而得到广泛应用。本研究采用DXS 101、DXS 10159、DXS 10162、DXS 10164、DXS 6789、DXS 7133、DXS 7423、DXS 7424、DXS 8378、DXS 981、GATA 165 B12、GATA 31 E08等12个X-STR基因座对宁夏回族231名健康个体进行群体遗传学研究，中国分别对12个X-STR基因座的等位基因频率和已报道的连锁群（DXS 7424-DXS 101和DXS 10159-DXS 10164-DXS 10162）的单倍型频率进行了调查。经Bonferroni校正后，未发现STR位点偏离Hardy-Weinberg平衡，也未发现两两位点间存在连锁不平衡。女性个体的综合辨别力为0.99999999985，男性个体的综合辨别力为0.99999967。在缺乏病例、正常三人组和二人组中，合并平均排除机会分别为0.999934、0.995754和0.999796。回族群体与其他16个群体的基因型数据比较，在0 ~ 8个位点上均存在显著性差异。结果表明，新的12个X-STR基因座组合具有一定的法医学应用价值。
X-chromosomal STRs (X-STRs) have been used as complements of autosomal STR application in recent years. In this work, we present population genetic data of 12 X-STRs including DXS101, DXS10159, DXS10162, DXS10164, DXS6789, DXS7133, DXS7423, DXS7424, DXS8378, DXS981, GATA165B12, and GATA31E08 loci in a sample of 231 unrelated healthy individuals from the Hui ethnic group in Ningxia Hui Autonomous Region, China. Allelic frequencies of the 12 X-STR loci and haplotypic frequencies of the reported linkage groups (DXS7424-DXS101 and DXS10159-DXS10164-DXS10162) were investigated in the group, respectively. No STR loci showed significant deviations from the Hardy-Weinberg equilibriums and no linkage disequilibriums of pairwise loci were found after Bonferroni correction, respectively. A combined power of discrimination in female individuals was 0.999999999985 and that in male individuals was 0.99999967, respectively. The combined mean exclusion chance in deficiency cases, normal trios and duo cases were 0.999934, 0.995754, and 0.999796, respectively. Significant differences were observed from 0 to 8 loci, when making comparisons between the data of Hui ethnic group and previously reported data from other 16 populations. The results indicated the new panel of 12 X-STR loci might be useful for forensic science application.