Evaluating hypercoagulability in new-onset systemic lupus erythematosus patients using thromboelastography
Evaluating hypercoagulability in new-onset systemic lupus erythematosus patients using thromboelastography
复制标题
使用血栓弹力图评估新发系统性红斑狼疮患者的高凝状态
DOI：
10.1002/jcla.23157
复制
发表时间：
2020
影响因子：
2.7
通讯作者：
Ye Junna
中科院分区：
文献类型：
--
作者：
Gong Huiyun;Shi Ce;Zhou Zhuochao;Teng Jialin;Sun Yue;Yang Chengde;Wang Xuefeng;Ye Junna
血栓弹力图（thromboelastography，TEG）可以反映体内从血栓形成到血栓溶解的凝血状态.在本研究中，我们的目的是评估功能TEG在检测凝血系统的SLE患者，并寻求探讨临床和实验室data.MethodsA共41例新发SLE谁没有经过治疗和56名健康对照者之间的相关性。TEG和其他实验室检查进行，并收集临床data.ResultsA的TEG反应时间和TEG实现凝块硬度组之间观察到显着差异。此外，这些参数与狼疮抗凝物水平、血小板计数、24 h尿总蛋白量和系统性红斑狼疮疾病活动指数（SLE disease activity index，SLE活动指数）相关。
BackgroundThromboelastography (TEG) can reflect the coagulation status in vivo, from clot formation to clot lysis. In the present study, we aimed to evaluate the function of TEG in detecting coagulation in patients with SLE and sought to explore the correlation between clinical and laboratory data.MethodsA total of 41 patients with new‐onset SLE who had not undergone treatment and 56 healthy controls were included. TEG and other laboratory tests were performed, and clinical data were collected.ResultsA significant difference in the TEG reaction time and TEG achievement of clot firmness was observed between the groups. Moreover, these parameters were correlated with the lupus anticoagulant levels, platelet count, 24‐hour urinary total protein quantity, and systemic lupus erythematosus disease activity index.ConclusionOur study demonstrated the prospective value of TEG in evaluating hypercoagulability in patients with SLE.