MONOCLONAL ANTIBODIES DEFINING DISTINCTIVE HUMAN T-CELL SURFACE-ANTIGENS
MONOCLONAL ANTIBODIES DEFINING DISTINCTIVE HUMAN T-CELL SURFACE-ANTIGENS
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DOI：
10.1126/science.314668
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发表时间：
1979-01-01
期刊：
影响因子：
56.9
通讯作者：
SCHLOSSMAN, SF
中科院分区：
文献类型：
--
作者：
KUNG, PC;GOLDSTEIN, G;SCHLOSSMAN, SF
三种新的单克隆抗体（指定OKT 1，OKT 3，和OKT 4）产生对人外周血T细胞的表面决定簇。OKT 1和OKT 3均与所有人外周血T细胞和5%~ 10%的胸腺细胞反应，但与T细胞系的反应性不同。相比之下，OKT 4与55%的人外周T细胞和80%的胸腺细胞反应。所有三种抗体对外周血中的T细胞都是选择性的，因为它们不与正常B细胞、空细胞、单核细胞或粒细胞反应。
Three novel monoclonal antibodies (designated OKT1, OKT3, and OKT4) were generated against surface determinants of human peripheral T cells. Both OKT1 and OKT3 reacted with all human peripheral T cells and 5 to 10 percent of thymocytes but differed in their reactivities with T cell lines. By contrast, OKT4 reacted with 55 percent of human peripheral T cells and 80 percent of thymocytes. All three antibodies were selective for T cells in the peripheral blood in that they did not react with normal B cells, null cells, monocytes, or granulocytes.