Cryptorchidism in Children with Zika-Related Microcephaly
Cryptorchidism in Children with Zika-Related Microcephaly
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DOI：
10.4269/ajtmh.19-0753
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发表时间：
2020-05-01
影响因子：
3.3
通讯作者：
Miranda-Filho, Democrito de B.
中科院分区：
文献类型：
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作者：
de Vasconcelos, Romulo A. L.;Ximenes, Ricardo A. A.;Miranda-Filho, Democrito de B.
最近，泌尿生殖道被确定为先天性寨卡病毒综合征(CZS)相关并发症的潜在部位。我们提供了在2018年10月至2019年4月期间接受会诊的3岁寨卡病毒相关性小头畸形症儿童的一系列隐睾症病例的第一份报告，这是巴西伯南布哥小头畸形症流行研究小组儿童队列后续行动的一部分。在接受检查的22名男性中，8人(36.4%)表现为隐睾症。14例隐睾者中，11例(78.6%)可触及腹股沟。8名儿童中有7名患有严重的小头畸形症。在这些儿童中，隐睾症的常规危险因素相对较少。我们推测，隐睾症是严重小头畸形儿童CZS的另一种表现。在我们的病例中，对于大多数儿童来说，睾丸位于腹股沟区域，隐睾症的可能机制是引带障碍或发育术异常。
The genitourinary tract was recently identified as a potential site of complications related to the congenital Zika syndrome (CZS). We provide the first report of a series of cryptorchidism cases in 3-year-old children with Zika-related microcephaly who underwent consultations between October 2018 and April 2019 as part of the follow-up of the children cohort of the Microcephaly Epidemic Research Group, Pernambuco, Brazil. Of the 22 males examined, eight (36.4%) presented with cryptorchidism. Among 14 undescended testis cases, 11 (78.6%) could be palpated in the inguinal region. Seven of the eight children had severe microcephaly. Conventional risk factors for cryptorchidism were relatively infrequent in these children. We hypothesize that cryptorchidism is an additional manifestation of CZS present in children with severe microcephaly. As in our cases, for most of the children, the testes were located in the inguinal region, and the possible mechanisms for cryptorchidism were gubernaculum disturbance or cremasteric abnormality.