Meta-analysis of the effect of comprehensive smoke-free legislation on acute coronary events
Meta-analysis of the effect of comprehensive smoke-free legislation on acute coronary events
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DOI：
10.1136/hrt.2010.199026
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发表时间：
2010-10-01
期刊：
影响因子：
5.7
通讯作者：
Pell, J. P.
中科院分区：
文献类型：
--
作者：
Mackay, D. F.;Irfan, M. O.;Pell, J. P.
目的评估全面无烟立法降低急性冠状动脉事件风险的证据。方法使用PubMed、Embase和Science Direct进行两项独立的系统评价，不设日期限制。使用随机效应模型进行荟萃分析，以获得相对风险的汇总估计。结果17项合格研究(10项来自北美，6项来自欧洲，1项来自澳大拉西亚)提供了35个效应大小的估计。除了五个亚组的分析外，所有发表的结果都表明引入无烟立法后急性冠状动脉事件的发生率降低。Meta分析得出合并后的相对危险度为0.90(95%CI为0.86~0.94)。有显著异质性(总体I-2=95.1%，p
Objective To assess the evidence for a reduced risk of acute coronary events following comprehensive smoke-free legislation.Methods Two independent systematic reviews were undertaken using PubMed, Embase and Science Direct with no date restrictions imposed. Meta-analysis was undertaken using a random effects model to obtain a pooled estimate of the relative risk. Linear regression was used to examine possible bias and meta-regression was used to investigate possible causes of heterogeneity.Main outcome measure Acute coronary events.Results The 17 eligible studies (10 from North America, 6 from Europe and 1 from Australasia) provided 35 estimates of effect size. Apart from five subgroup analyses, all of the published results suggested a reduction in the incidence of acute coronary events following the introduction of smoke-free legislation. Meta-analysis produced a pooled estimate of the relative risk of 0.90 (95% CI 0.86 to 0.94). There was significant heterogeneity (overall I-2=95.1%, p