Global variation in grip strength: a systematic review and meta-analysis of normative data.
Global variation in grip strength: a systematic review and meta-analysis of normative data.
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DOI：
10.1093/ageing/afv192
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发表时间：
2016-03
期刊：
影响因子：
6.7
通讯作者：
Sayer AA
中科院分区：
文献类型：
--
作者：
Dodds RM;Syddall HE;Cooper R;Kuh D;Cooper C;Sayer AA
背景：握力弱是肌肉减少症的一个关键组成部分，并与随后的残疾和死亡率有关。我们最近在英国建立了握力的生命过程规范数据，但目前还不清楚我们推导出的弱握力临界点是否适用于其他环境。我们的目的是使用我们的数据作为参考标准，调查世界各地区的握力差异。方法：我们检索MEDLINE和EMBASE，以报告握力的年龄和性别分层的规范性数据。我们提取了每一项规范性数据，并将其转换为相对于英国百分位数的Z评分量表。我们进行了元回归，以汇集Z分数，并按世界地区进行比较。结果：我们的检索返回了806篇摘要。60篇论文符合纳入标准，报告了63个不同的样本。有7个联合国区域的代表，虽然大多数样本（n = 44）是在发达地区。我们提取了与96，537个握力观察结果相关的726个规范性数据项。来自发达地区的规范性数据与我们的英国百分位数大致相似，合并Z评分0.12 SD（95% CI：0.07，0.17）高于相应的英国百分位数。相比之下，发展中地区的规范性数据明显较低，合并Z得分为-0.85 SD（95% CI：-0.94，-0.76）。释义：我们的研究结果支持使用我们的英国握力百分位数及其相关的分界点在发达地区对肌肉减少症和虚弱的共识定义中，但强调了在发展中地区需要不同的分界点。
Background: weak grip strength is a key component of sarcopenia and is associated with subsequent disability and mortality. We have recently established life course normative data for grip strength in Great Britain, but it is unclear whether the cut points we derived for weak grip strength are suitable for use in other settings. Our objective was to investigate differences in grip strength by world region using our data as a reference standard. Methods: we searched MEDLINE and EMBASE for reporting age- and gender-stratified normative data for grip strength. We extracted each item of normative data and converted it on to a Z-score scale relative to our British centiles. We performed meta-regression to pool the Z-scores and compare them by world region. Findings: our search returned 806 abstracts. Sixty papers met inclusion criteria and reported on 63 different samples. Seven UN regions were represented, although most samples (n = 44) were based in developed regions. We extracted 726 normative data items relating to 96,537 grip strength observations. Normative data from developed regions were broadly similar to our British centiles, with a pooled Z-score 0.12 SDs (95% CI: 0.07, 0.17) above the corresponding British centiles. By comparison, normative data from developing regions were clearly lower, with a pooled Z-score of −0.85 SDs (95% CI: −0.94, −0.76). Interpretation: our findings support the use of our British grip strength centiles and their associated cut points in consensus definitions for sarcopenia and frailty across developed regions, but highlight the need for different cut points in developing regions.