Hypertension and breast cancer risk in a 19-year foIlow-up study (the DOM cohort)
Hypertension and breast cancer risk in a 19-year foIlow-up study (the DOM cohort)
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DOI：
10.1097/00004872-200018030-00002
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发表时间：
2000-03-01
影响因子：
4.9
通讯作者：
Grobbee, DE
中科院分区：
文献类型：
--
作者：
Peeters, PHM;van Noord, PAH;Grobbee, DE
背景：研究高血压和抗高血压药物的使用是否与乳腺癌风险相关。方法这是一项前瞻性研究，研究对象为居住在荷兰乌得勒支的11 011名参加乳腺癌筛查项目(DOM队列)、年龄在50-65岁之间的女性。妇女参加了1974至1985年间的筛查，在这些筛查中测量了血压，并确定了有关药物使用和乳腺癌风险因素的信息。自1974年(中位随访时间19年)以来，有关乳腺癌发生和死亡的信息已有记录，高血压被定义为收缩压和舒张压分别为160毫米汞柱或舒张压。结果523例确诊为乳腺癌的女性中，高血压患者乳腺癌风险增加23%(年龄调整风险比HRA=1.23；年龄调整风险比(HRA)=1.23；95%可信区间(CI)1.01~1.49)，调整所有混杂因素后，增加14%(HR=1.14；95%CI 0.93~1.40)。风险的下降主要归因于体重指数的影响，在接受治疗的高血压妇女(HR=1.22；95%CI为0.91-1.63)和未治疗的高血压妇女(HR=1.13；95%可信区间0.91-1.40)，结论这些结果不支持高血压与乳腺癌之间的联系，如果存在联系，则很可能是正数且范围相对较小(+14%)，如果存在这种联系，则不能归因于降压药物，因为这种关系也存在于非吸毒者中，J Hyperten 2000，18：249-254(C)Lippincott Williams&Wilkins。
Background To investigate whether hypertension and the use of anti-hypertensive drugs are associated with breast cancer risk.Methods This was a prospective study of 11 011 women living in Utrecht, the Netherlands, aged 50-65 years at enrolment in a breast cancer screening project (DOM cohort). Women attended screening rounds between 1974 and 1985 at which blood pressure was measured and information on drug use and breast cancer risk factors was ascertained. Since 1974 (median follow-up time 19 years), information on breast cancer occurrence and death has been registered, Hypertension was defined as a systolic blood pressure > 160 mmHg or a diastolic blood pressure > 95 mmHg or current use of drugs for the indication hypertension, Cox's regression analysis was used to investigate the association between hypertension (treated or untreated) and subsequent breast cancer risk, Analyses were adjusted for age, body mass index, height, parity, familial breast cancer, smoking and oral contraceptive use,Results A total of 523 women were diagnosed with breast cancer, Hypertensive women experienced a statistically significant increased breast cancer risk of 23% (age-adjusted hazard ratio (HRa) = 1.23; 95% confidence interval (CI) 1.01-1.49), After adjustment for all confounders, the increase was 14% (HR =1.14; 95% CI 0.93-1.40). The decline in risk was mainly attributable to the effect of BMI, The risk was similar in treated (HR = 1.22; 95% CI 0.91-1.63) and untreated hypertensive women (HR = 1.13; 95% CI 0.91-1.40),Conclusion These results do not support an association between hypertension and breast cancer, and if there is a link, it is likely to be positive and relatively small in size (+14%), This relation, if present, is not attributable to antihypertensive drugs, since the relation is also present in non-drug users, J Hypertens 2000, 18:249-254 (C) Lippincott Williams & Wilkins.