Circulating retinol-binding protein 4 and metabolic syndrome in the elderly
Circulating retinol-binding protein 4 and metabolic syndrome in the elderly
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DOI：
10.1007/s10354-011-0885-7
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发表时间：
2011-11-01
影响因子：
0.9
通讯作者：
Fischer, Peter
中科院分区：
文献类型：
--
作者：
Mostafaie, Nazanin;Sebesta, Christian;Fischer, Peter
背景资料：视黄醇结合蛋白（RBP）4是一种与视黄醇特异性结合的脂肪因子，在肥胖和胰岛素抵抗之间有一定的联系，其血浆浓度可能受年龄和肥胖的影响，但只有少数研究在老年人中探讨了这种联系。因此，我们在一项老年人的大型人群队列研究（VITA）中测试了RBP 4浓度与2型糖尿病/代谢综合征（MetS）组分之间的相关性[1，2]。使用单个出生队列，本研究可以排除年龄的影响。研究方法：我们评估了RBP 4与2型糖尿病和MetS组分的相关性，包括体重指数（BMI），血压，血脂参数，空腹血糖胰岛素，稳态模型评估胰岛素抵抗（HOMA-IR），以及75-76岁参与者（N = 232）的吸烟。在本研究中，RBP 4浓度与2型糖尿病和代谢综合征（MetS）组分相关。在与RBP 4浓度相关的代谢综合征的所有个体成分中，RBP 4与血清甘油三酯的相关性和与HDL的负相关性是我们研究队列中观察到的最强的相关性（p < 0.0001）。
Background: Retinol-binding protein (RBP) 4, a human adipokine that specifically binds to retinol, has been reported to provide a link between obesity and insulin resistance.Plasma RBP4 concentration may be under the influence of age and obesity, but only a few studies has investigated this link in elderly individuals. Consequently, we tested the correlation between RBP4 concentrations and type 2 diabetes/metabolic syndrome (MetS) components in a large population based cohort study (VITA) of elderly [1, 2]. Using a single birth cohort, this investigation could exclude the influence of age. Methods: We evaluated the correlation of RBP4 with type 2 diabetes and MetS components including Body Mass Index (BMI), blood pressure, lipid parameters, fasting glucose insulin, homeostasis model assessment insulin resistance (HOMA-IR), and smoking in exclusively 75-76 year old participants (N = 232).Results: In the present study, RBP4 concentrations were associated with type 2 diabetes and metabolic syndrome (MetS) components. Of all the individual components of metabolic syndrome that were associated with RBP4 concentrations, the correlations of RBP4 with serum triglycerides and a negative correlation with HDL were the strongest ones observed in our study cohort (p < 0.0001).Conclusions: RBP4 plays a role in biological mechanisms that are responsible for insulin resistance and development of type 2 diabetes.