Preoperative apolipoprotein CI levels correlate positively with the proinflammatory response in patients experiencing endotoxemia following elective cardiac surgery.
Preoperative apolipoprotein CI levels correlate positively with the proinflammatory response in patients experiencing endotoxemia following elective cardiac surgery.
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DOI：
10.1007/s00134-008-1077-9
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发表时间：
2008-08
影响因子：
38.9
通讯作者：
van Dissel, Jaap T.
中科院分区：
文献类型：
--
作者：
Schippers, Emile F.;Berbee, Jimmy F. P.;van Disseldorp, Inge M.;Versteegh, Michael I. M.;Havekes, Louis M.;Rensen, Patrick C. N.;van Dissel, Jaap T.
实验模型表明，载脂蛋白 CI (apoCI) 结合并增强内毒素的炎症反应。我们在接受体外循环手术 (CPB) 并在再灌注期间出现内毒素血症的患者中研究了血浆 apoCI 水平是否与炎症反应和围手术期细胞因子释放相关。前瞻性、观察性、临床队列研究。大学医院的手术室 (OR) 和重症监护室 (ICU)。连续 159 名年龄>18 岁的患者（66% 为男性（n=105），男性和女性中位年龄分别为 65 岁和 67 岁）接受体外循环择期心胸手术。没有任何。测定基线 apoCI、apoCIII、总胆固醇和甘油三酯水平以及围手术期内毒素和 TNF-α 水平。内毒素血症患者术前血浆 apoCI（而非 apoCIII）水平较高与围手术期 TNF-α 水平升高相关（p<0.05）。在没有内毒素血症的患者中没有观察到这种关联。高血浆 apoCI 与内毒素血症患者的促炎反应呈正相关，并证实了动物模型中的观察结果。
Experimental models show that apolipoprotein CI (apoCI) binds and enhances the inflammatory response to endotoxin. We studied in patients undergoing cardiopulmonary bypass surgery (CPB) and experiencing endotoxemia during reperfusion whether plasma apoCI levels correlate with the inflammatory response and perioperative cytokine release. Prospective, observational, clinical cohort study. Operating room (OR) and intensive care unit (ICU) of a university hospital. One hundred fifty-nine consecutive patients > 18 years of age (66% males (n = 105), median age 65 and 67 years for males and females, respectively) undergoing elective cardiothoracic surgery with cardiopulmonary bypass. None. Baseline apoCI, apoCIII, total cholesterol and triglyceride levels, and perioperative endotoxin and TNF-α levels were determined. High preoperative plasma apoCI, but not apoCIII, levels were associated (p < 0.05) with increased perioperative levels of TNF-α in patients experiencing endotoxemia. This association was not observed in patients without endotoxemia. High plasma apoCI is positively related to proinflammatory response in patients experiencing endotoxemia and confirms the observations in animal models.
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影响因子：
15.9
作者：
Rensen, PCN;vanOosten, M;vanBerkel, TJC
通讯作者：
vanBerkel, TJC
影响因子：
11.8
作者：
van Langevelde, P;Joop, K;van Dissel, JT
通讯作者：
van Dissel, JT
影响因子：
6.5
作者：
Schaap, Frank G.;Nierman, Melchior C.;Groen, Albert K.
通讯作者：
Groen, Albert K.
DOI：
10.1016/s1053-0770(96)80235-7
发表时间：
1996-02-01
影响因子：
2.8
作者：
OudemansvanStraaten, HM;Jansen, PGM;Eysman, L
通讯作者：
Eysman, L
影响因子：
4.6
作者：
Rossi, M;Sganga, G;Silveri, NG
通讯作者：
Silveri, NG