EVIDENCE FOR A POSSIBLE FUNCTIONAL INTERACTION BETWEEN SEROTONERGIC AND CHOLINERGIC MECHANISMS IN MEMORY RETRIEVAL
EVIDENCE FOR A POSSIBLE FUNCTIONAL INTERACTION BETWEEN SEROTONERGIC AND CHOLINERGIC MECHANISMS IN MEMORY RETRIEVAL
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DOI：
10.1016/s0163-1047(87)90574-7
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发表时间：
1987-07-01
期刊：
影响因子：
--
通讯作者：
OGREN, SO
中科院分区：
文献类型：
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作者：
ALTMAN, HJ;STONE, WS;OGREN, SO
总共进行了三个实验。在实验1中，单独和组合在一项一次性的抑制性避免任务中评估了5-羟基甲酸甲酸酯和选择性毒蕈碱胆碱能类动力甲促性甲状腺素的剂量依赖性作用。由于所有三种治疗条件，证明了剂量依赖性依赖性的表现，这在药物对行为的非特异性影响方面无法解释。此外，观察到甲状腺酸盐和黄瓜的联合治疗产生的检索性能的促进，在剂量水平上观察到远低于单独施用两种化合物后观察到的剂量水平。在实验中，进行了2尝试，以通过不同的治疗条件（大甲酸甲酸酯，氧甲状腺素或大甲帕酸盐和氧氨酸酯）的组合来阻止保留率的增强，并通过将小鼠用scpolamine（一种毒蕈碱胆碱性拮抗剂或quipazine）（毒药）（毒药）（一种毒液毒剂）（蛇毒疗法）预处理。 ）。这些实验的结果表明，（a）二嗪完全阻断了甲状腺丙酸酯导致的检索的增强，但并未结合使用氧甲氨酸或黄脂蛋白与大丙酸酯结合使用，而（b）scopolamine却阻止了单独的牛remorine exotremorine Rectiremence and and and and and and and and oxotremine of oxotremorine。由大甲酸盐加上氧甲酸酯导致，但无法阻止由大理酸酯产生的内存增强。目前的结果对5-羟色胺和乙酰胆碱都在记忆检索中起重要作用的观点为进一步的支持提供了进一步的支持。更重要的是，本系列实验的结果为在行为介导中的血清素能和胆碱能神经系统之间的功能相互作用提供了额外的支持。
A total of three experiments were conducted. In Experiment 1, the dose-dependent effects of the pretest administration of the serotonergic agonist alaproclate and the selective muscarinic cholinergic agonist oxotremorine, alone and in combination, were assessed in a one-trial inhibitory avoidance task. A clear dose-dependent enhancement of performance was demonstrated as a result of all three treatment conditions, which could not be explained in terms of nonspecific effects of the drugs on behavior in general. In addition, the facilitation of retrieval performance produced by the combined treatment of alaproclate and oxotremorine was observed at dose levels well below those observed following administration of either compound alone. In Experiment 2 attempts were made to block the enhancements of retention resulting from the different treatment conditions (alaproclate, oxotremorine, or the combination of alaproclate and oxotremorine) by pretreating the mice with either scopolamine (a muscarinic cholinergic antagonist) or quipazine (a serotonergic agonist). The results of these experiments indicate that (a) quipazine completely blocked the enhancement of retrieval resulting from alaproclate but not that following oxotremorine or oxotremorine in combination with alaproclate, while (b) scopolamine blocked the enhancement of retrieval resulting from oxotremorine alone as well as that resulting from alaproclate plus oxotremorine but failed to block the memory enhancement resulting from alaproclate. The present results lend further support to the view that both serotonin and acetylcholine play important roles in memory retrieval. More importantly, the results of the present series of experiments provide additional support for a functional interaction between the serotonergic and cholinergic nervous systems in the mediation of behavior.