Family study of affective spectrum disorder
Family study of affective spectrum disorder
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DOI：
10.1001/archpsyc.60.2.170
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发表时间：
2003-02-01
影响因子：
--
通讯作者：
Tsuang, MT
中科院分区：
文献类型：
--
作者：
Hudson, JI;Mangweth, B;Tsuang, MT
背景资料：情感谱系障碍（ASD）代表了一组精神和医学疾病，每种疾病都对几种化学家族的抗抑郁药物有反应，因此可能与常见的遗传异常有关。ASD的形式包括重度抑郁症（MDD）、注意力缺陷/多动障碍、神经性贪食症、紧张症、心境恶劣障碍、纤维肌痛、广泛性焦虑症、肠易激综合征、偏头痛、强迫症、恐慌症、创伤后应激障碍、经前焦虑症和社交恐惧症。两个预测的ASD假设进行了测试：ASD，作为一个单一的实体，将聚集在家庭中，MDD将与其他形式的ASD在family.Methods：先证者与MDD和没有，连同他们的一级亲属，进行了采访，使用结构化的临床访谈DSM-IV和其他形式的ASD的补充采访。使用先证者预测逻辑回归模型分析疾病的家族聚集性和共聚集性，包括一种新的双变量模型，用于预测相关先证者中2种疾病中每种疾病的存在或不存在。在64名MDD先证者的178名亲属和58名非MDD先证者的152名亲属中，估计的比值比ASD家族聚集性的95%可信区间为2.5（1.4-4.3; P=.001），MDD与至少一种其他形式ASD的家族共聚集性为1.9结论：情感谱系障碍在家族中聚集性很强，MDD与其他形式的ASD有显著的家族共聚集性。这些结果表明，ASD的形式可能共享遗传的病理生理特征。
Background: Affective spectrum disorder (ASD) represents a group of psychiatric and medical conditions, each known to respond to several chemical families of antidepressant medications and hence possibly linked by common heritable abnormalities. Forms of ASD include major depressive disorder (MDD), attention-deficit/ hyperactivity disorder, bulimia nervosa, cataplexy, dysthymic disorder, fibromyalgia, generalized anxiety disorder, irritable bowel syndrome, migraine, obsessive-compulsive disorder, panic disorder, posttraumatic stress disorder, premenstrual dysphoric disorder, and social phobia. Two predictions of the ASD hypothesis were tested: that ASD, taken as a single entity, would aggregate in families and that MDD would coaggregate with other forms of ASD in families.Methods: Probands with and without MDD, together with their first-degree relatives, were interviewed using the Structured Clinical Interview for DSM-IV and a supplemental interview for other forms of ASD. The familial aggregation and coaggregation of disorders were analyzed using proband predictive logistic regression models, including a novel bivariate model for the presence or absence of each of 2 disorders in a relative as predicted by the presence or absence of each, of 2 disorders in the associated proband.Results: In the 178 interviewed relatives of 64 probands with MDD and 152 relatives of 58 probands without MDD, the estimated odds ratio (95% confidence interval) for the familial aggregation of ASD as a whole was 2.5 (1.4-4.3; P=.001) and for the familial coaggregation of MDD with at least one other form of ASD was 1.9 (1.1-3.2; P=.02).Conclusions: Affective spectrum disorder aggregates strongly in families, and MDD displays a significant familial coaggregation with other forms of ASD, taken collectively. These results suggest that forms of ASD may share heritable pathophysiologic features.