5'-O-D-valyl ara A, a potential prodrug for improving oral bioavailability of the antiviral agent vidarabine.
5'-O-D-valyl ara A, a potential prodrug for improving oral bioavailability of the antiviral agent vidarabine.
复制标题
5-O-D-valyl ara A，一种潜在的前药，可提高抗病毒药物阿糖腺苷的口服生物利用度。
DOI：
10.1080/15257770802581757
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Hilfinger,John
中科院分区：
文献类型：
--
作者：
Shen,Wei;Kim,Jae-Seung;Mitchell,Stefanie;Kish,Phil;Kijek,Paul;Hilfinger,John
In order to improve the oral bioavailability of Adenine 9-β-D-arabinofuranoside (Vidarabine, also calledaraA), an antiviral drug which is active against herpes simplex and varicella zoster viruses and the first agent to be licensed for the treatment of systematic herpes virus infection in man, the corresponding 5′-O-D-valyl ester derivative has been synthesized. Based on their physicochemical properties, 5′-O-valylaraA has emerged as a potential prodrug candidate to improve the oral bioavailability of vidarabine. We describe in this paper a facile synthesis route for the prodrug and its physicochemical properties.
