Serum miR-122 levels are related to coagulation disorders in sepsis patients
Serum miR-122 levels are related to coagulation disorders in sepsis patients
复制标题
脓毒症患者血清miR-122水平与凝血障碍相关
DOI：
10.1515/cclm-2013-0899
复制
发表时间：
2014-06-01
影响因子：
6.8
通讯作者：
Xie, Li-Xin
中科院分区：
文献类型：
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作者：
Wang, Hui-Juan;Deng, Jie;Xie, Li-Xin
背景：凝血功能异常可能对脓毒症患者的预后有重要影响。方法：收集123例脓毒症患者入院当天和45例脓毒症患者入院后第1、3、5、7、10、14天的血样。用定量逆转录聚合酶链式反应检测miR-223、miR-15a、miR-16、miR-122、miR-193B*和miR-483-5p的表达水平。根据国际血栓和止血学会(ISTH)弥散性血管内凝血(DIC)评分，将脓毒症患者分为凝血异常(CA)组和凝血正常(CN)组。
Background: Coagulation abnormalities may have a major impact on the outcome of sepsis in patients. This study aimed to explore the relationship between miRNA levels and coagulation disorders during sepsis.Methods: Blood samples from 123 sepsis patients were collected on the day of admission and another 45 sepsis patients on days 1, 3, 5, 7, 10, and 14 following admission to the intensive care unit. miR-223, miR-15a, miR-16, miR-122, miR-193b*, and miR-483-5p levels were evaluated by quantitative reverse transcription polymerase chain reaction. Based on the International Society on Thrombosis and Haemostasis (ISTH) Disseminated Intravascular Coagulation (DIC) score, sepsis patients were divided into coagulation abnormal (CA) group and coagulation normal (CN) group.Results: Only the levels of miR-122 were significantly higher in CA patients than in CN patients (p