Prognostic value of serum high-density lipoprotein cholesterol in patients with gallbladder cancer.
Prognostic value of serum high-density lipoprotein cholesterol in patients with gallbladder cancer.
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DOI：
10.17235/reed.2019.6201/2019
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发表时间：
2019-11
期刊：
影响因子：
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通讯作者：
Bo Yuan;J. Fu;Wen-long Yu;Xiao-hui Fu;Y. Qiu;L. Yin;B. Zhu;Yong-jie Zhang
中科院分区：
文献类型：
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作者：
Bo Yuan;J. Fu;Wen-long Yu;Xiao-hui Fu;Y. Qiu;L. Yin;B. Zhu;Yong-jie Zhang
本研究的目的是评估术前血脂对胆囊癌患者预后的意义。方法回顾性分析2009年10月至2013年12月期间99例GBC患者。术前测定血清总胆固醇（TC）、总甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白A（Apo-A）、载脂蛋白B（Apo-B）和游离脂肪酸（FFA）。采用单因素和多因素生存分析方法，分析血脂水平与患者性别、年龄、肿瘤大小、淋巴结转移、肿瘤分化程度、远处转移和TNM分期等临床资料的相关性。结果与HDL-C正常组（n = 57）相比，低HDL-C水平GBC患者（n = 42）的总生存率降低（p < 0.05）。然而，TC、TG、Apo-A、Apo-B、LDL-C或FFA水平不同的患者的总生存期无显著差异。血清HDL-C水平与TNM分期（p < 0.05）和远处转移（p < 0.001）有关。多因素预后分析显示HDL-C和淋巴结转移是独立的预后因素（p < 0.05）。建立了基于HDL-C和淋巴结转移的预后评估模型。结论术前血清HDL-C水平与胆囊癌远处转移密切相关。HDL-C水平可能是GBC患者的一个有价值的预后指标。HDLC与淋巴结转移联合检测可更好地预测GBC的预后。
OBJECTIVES the aim of this study was to evaluate the prognostic significance of preoperative serum lipid in patients with gallbladder cancer (GBC). METHODS ninety-nine patients with GBC between October 2009 and December 2013 were reviewed in this retrospective study. Total serum cholesterol (TC), total triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein A (Apo-A), apolipoprotein B (Apo-B) and free fatty acids (FFA) were measured before surgery. The correlation of serum lipid levels with clinical data, including gender, age, tumor size, lymph nodes metastasis, tumor differentiation, distant metastasis and TNM stage were analyzed by univariate and multivariate survival analysis to evaluate independent prognostic factors. RESULTS compared with the normal HDL-C group (n = 57), the overall survival rate among GBC patients with low HDL-C levels (n = 42) was reduced (p < 0.05). However, there were no significant differences in overall survival for patients with different levels of TC, TG, Apo-A, Apo-B, LDL-C or FFA. The serum level of HDL-C was associated with TNM stage (p < 0.05) and distant metastasis (p < 0.001). The multivariate prognosis analysis showed that HDL-C and lymph nodes metastasis were independent prognostic factors (p < 0.05). A prognostic evaluation model based on HDL-C and lymph nodes metastasis was established. CONCLUSION preoperative serum HDL-C level was closely associated with distant metastasis of patients with GBC. HDL-C level may be a valuable prognostic factor for GBC patients. The combination of HDLC and lymph nodes metastasis can better predict the prognosis of GBC.