Dietary patterns and C-reactive protein in Japanese men and women
Dietary patterns and C-reactive protein in Japanese men and women
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DOI：
10.1093/ajcn/87.5.1488
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发表时间：
2008-05-01
影响因子：
7.1
通讯作者：
Kono, Suminori
中科院分区：
文献类型：
--
作者：
Nanri, Akiko;Yoshida, Daigo;Kono, Suminori
背景：炎症可能参与动脉粥样硬化、2型糖尿病和癌症的发病机制。许多研究报道了特定食物和营养素与炎症的关系，但很少有研究探讨饮食模式与炎症标志物的关系。目的：我们调查了日本男性和女性的饮食模式与循环高敏C反应蛋白（hs-CRP）之间的关系。设计：受试者是2004年2月至2006年7月期间正在进行的生活方式相关疾病队列研究的基线调查的参与者。我们排除了患有限制生命或可能与炎症有关的疾病的人以及使用止痛药的人。在进一步排除CRP浓度> 3 mg/L的受试者后，7802例受试者仍留在分析中。饮食模式来自主成分分析的49个食品项目的消费频率确定的食物频率questionnaire.Results：我们确定了4种饮食模式：健康，高脂肪，海鲜，西式早餐模式。健康的饮食模式，其特点是高摄入量的蔬菜，水果，豆制品，和鱼，显着和hs-CRP浓度呈负相关，即使调整后的年龄，体重指数，吸烟，饮酒，和体力活动的男性和女性。虽然hs-CRP浓度略有升高的人与高分的海鲜模式，多变量调整的平均值并没有显示出显着的趋势。结论：健康的饮食结构可能与炎症抑制有关。
Background: Inflammation may be involved in the pathogenesis of atherosclerosis, type 2 diabetes mellitus, and cancer. Many studies have reported the relation of specific foods and nutrients to inflammation, but few studies have examined the relation of dietary patterns to inflammatory markers.Objective: We investigated the relation between dietary patterns and circulating high-sensitivity C-reactive protein (hs-CRP) in Japanese men and women.Design: The subjects were participants in the baseline survey of an ongoing cohort study of lifestyle-related diseases between February 2004 and July 2006. We excluded persons with life-limiting or possible inflammation-related diseases and those using analgesics. After further exclusion of subjects with a CRP concentration > 3 mg/L, 7802 subjects remained in the analysis. The dietary patterns were derived from principal component analysis of the frequency of consumption of 49 food items ascertained by the food-frequency questionnaire.Results: We identified 4 dietary patterns: healthy, high-fat, seafood, and Westernized breakfast patterns. The healthy dietary pattern, characterized by high intakes of vegetables, fruit, soy products, and fish, was significantly and inversely related to hs-CRP concentrations, even after adjustment for age, body mass index, smoking, alcohol consumption, and physical activity in both men and women. Although hs-CRP concentrations were slightly elevated in persons with a high score for the seafood pattern, multivariate-adjusted means did not show a significant trend. Neither the high-fat dietary pattern nor the Westernized breakfast pattern was related to hs-CRP concentrations.Conclusion: The healthy dietary pattern may be related to suppression of inflammation.