Emerging roles of HOTAIR in human cancer
Emerging roles of HOTAIR in human cancer
复制标题
HOTAIR 在人类癌症中的新作用。
DOI：
10.1002/jcb.29591
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发表时间：
2020-01-14
影响因子：
4
通讯作者：
Pan, Yunbao
中科院分区：
文献类型：
--
作者：
Yuan, Chunjue;Ning, Yong;Pan, Yunbao
HOX反义基因间RNA（HOTAIR）在许多类型的癌症中过表达，大量证据表明癌症与HOTAIR之间存在联系。本文就HOTAIR的结构和生物学功能作一综述，以阐明其在肿瘤发生发展中的分子机制。HOTAIR促进癌细胞增殖、侵袭和迁移，并抑制癌细胞凋亡。HOTAIR还通过调节炎症和免疫信号参与癌症的发病机制和进展。这些发现表明HOTAIR是人类癌症的新生物标志物。
Long noncoding RNA HOX antisense intergenic RNA (HOTAIR) is overexpressed in many types of cancers, and substantial evidence has suggested a link between cancers and HOTAIR. In the present study, we reviewed the structure and the corresponding biologic function of HOTAIR to clarify its molecular mechanism in cancer progression. HOTAIR promotes proliferation, invasion, and migration, and inhibits apoptosis in cancer cells. HOTAIR also participates in the pathogenesis and progression of cancer by regulating inflammation and immune signaling. These findings suggested that HOTAIR is a novel biomarker in human cancers.