Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells
Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells
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DOI：
10.1038/s41590-018-0082-6
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发表时间：
2018-05-01
影响因子：
30.5
通讯作者：
Romagnani, Chiara
中科院分区：
文献类型：
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作者：
Hammer, Quirin;Rueckert, Timo;Romagnani, Chiara
自然杀伤(NK)细胞是先天淋巴细胞，缺乏抗原特异性重排受体，这是适应性淋巴细胞的标志。在一些人巨细胞病毒(HCMV)感染者中，表达激活受体NKG2C的NK细胞亚群经历了部分类似于抗病毒适应性反应的克隆性扩张。然而，驱动适应性NKG2C(+)NK细胞活化和分化的病毒配体仍不清楚。在这里，我们发现适应性NKG2C(+)NK细胞不同地识别编码可变的UL40多肽的不同的HCMV毒株，这些多肽与促炎信号相结合，控制适应性NKG2C(+)NK细胞的群体扩张和分化。因此，我们认为，多态的HCMV多肽有助于在HCMV血清阳性人群中形成适应性NKG2C(+)NK细胞群体的异质性。
Natural killer (NK) cells are innate lymphocytes that lack antigen-specific rearranged receptors, a hallmark of adaptive lymphocytes. In some people infected with human cytomegalovirus (HCMV), an NK cell subset expressing the activating receptor NKG2C undergoes clonal-like expansion that partially resembles anti-viral adaptive responses. However, the viral ligand that drives the activation and differentiation of adaptive NKG2C(+) NK cells has remained unclear. Here we found that adaptive NKG2C(+) NK cells differentially recognized distinct HCMV strains encoding variable UL40 peptides that, in combination with pro-inflammatory signals, controlled the population expansion and differentiation of adaptive NKG2C(+) NK cells. Thus, we propose that polymorphic HCMV peptides contribute to shaping of the heterogeneity of adaptive NKG2C(+) NK cell populations among HCMV-seropositive people.