Visceral obesity as a risk factor for colorectal neoplasm
Visceral obesity as a risk factor for colorectal neoplasm
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DOI：
10.1111/j.1440-1746.2007.05125.x
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发表时间：
2008-03-01
影响因子：
4.1
通讯作者：
Kim, Jin-Ho
中科院分区：
文献类型：
--
作者：
Oh, Tae-Hoon;Byeon, Jeong-Sik;Kim, Jin-Ho
背景和目的：肥胖作为结直肠肿瘤（CRN）的危险因素是有争议的。在本研究中，我们评估内脏肥胖作为一个危险因素CRN.Methods：我们前瞻性地纳入了200个连续的，无症状的成年人（男性：女性= 133：67，平均年龄，50.9 +/- 8.5岁）进行结肠镜检查和腹盆腔计算机断层扫描（CT）扫描常规健康评估。在结肠镜检查中确定CRN的存在与否及其特征。通过腹盆CT扫描测量内脏脂肪组织（VAT）和皮下脂肪组织的量。测量体重指数、腰围和体脂百分比。结果：200例患者中，53例（26.5%）有CRN。老年、吸烟、代谢综合征和高空腹血糖水平与CRN风险增加相关。CRN患者的增值税（P < 0.01）和腰围（P = 0.01）明显较高。CRN风险的多变量分析显示，VAT大于136.61 cm（2）的患者相对于VAT小于67.23 cm（2）的患者的比值比为4.07（95%置信区间：1.01-16.43，P = 0.03）。腰围、代谢综合征和空腹血糖水平不是CRN的独立危险因素。结论：VAT增加是CRN的独立危险因素。需要进一步的大规模研究来阐明VAT和CRN之间的因果关系。
Background and Aim: Obesity as a risk factor for colorectal neoplasm (CRN) is controversial. In the present study, we evaluated visceral obesity as a risk factor for CRN.Methods: We prospectively enrolled 200 consecutive, asymptomatic adults (male : female = 133:67, mean age, 50.9 +/- 8.5 years) undergoing both colonoscopy and abdominopelvic computed tomography (CT) scan for routine health evaluations. The presence or absence and the characteristics of CRN were determined during colonoscopy. The amount of visceral adipose tissue (VAT) and subcutaneous adipose tissue was measured by an abdominopelvic CT scan. Body mass index, waist circumference, and percentage of body fat were measured. Blood pressure and other blood markers for assessing the metabolic syndrome were also investigated.Results: Of the 200 patients, 53 (26.5%) had CRN. Old age, smoking, metabolic syndrome, and a high fasting plasma glucose level were associated with an increased risk of CRN. VAT (P < 0.01) and waist circumference (P = 0.01) were significantly higher in those with CRN. A multivariate analysis of the risks of CRN showed an odds ratio of 4.07 (95% confidence interval: 1.01-16.43, P = 0.03) for those with VAT over 136.61 cm(2) relative to those with VAT under 67.23 cm(2). Waist circumference, metabolic syndrome, and fasting plasma glucose levels were not independent risk factors for CRN in the multivariate analysis.Conclusion: Increased VAT is an independent risk factor for CRN. Further large scale studies are needed to clarify the causal relationship between VAT and CRN.