MicroRNAs in the Blood-Brain Barrier in Hypoxic-Ischemic Brain Injury.
MicroRNAs in the Blood-Brain Barrier in Hypoxic-Ischemic Brain Injury.
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DOI：
10.2174/1570159x18666200429004242
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发表时间：
2020
影响因子：
5.3
通讯作者：
Ma Q
中科院分区：
文献类型：
--
作者：
Shen G;Ma Q
缺氧缺血性（HI）脑损伤是新生儿急性死亡和慢性残疾的主要原因。目前的证据表明，脑微血管反应和受损的血脑屏障（BBB）的完整性迅速发生，并可能主要负责在许多婴儿HI脑损伤中观察到的脑损伤。microRNA（miRNAs）是一类高度保守的非编码RNA（ncRNA），长度为21-25个核苷酸，通常导致靶基因表达的抑制。越来越多的证据表明，脑富集的miRNA在包括新生儿HI脑损伤在内的各种神经系统疾病中充当BBB功能障碍的多功能调节剂。本文就miRNAs在缺氧缺血性脑损伤后血脑屏障损伤中的作用进行综述。具体而言，我们专注于最近的进展，miRNAs在新生儿HI脑损伤的病理。这些发现不仅可以加深我们对miRNAs在HI脑损伤中BBB损伤中的作用的理解，还可以为在病理条件下保护BBB完整性的新治疗策略的开发提供见解。
Hypoxic-ischemic (HI) brain injury is a leading cause of acute mortality and chronic disability in newborns. Current evidence shows that cerebral microvascular response and compromised blood-brain barrier (BBB) integrity occur rapidly and could primarily be responsible for the brain injury observed in many infants with HI brain injury. MicroRNAs (miRNAs) are a type of highly conserved non-coding RNAs (ncRNAs), which consist of 21-25 nucleotides in length and usually lead to suppression of target gene expression. Growing evidence has revealed that brain-enriched miRNAs act as versatile regulators of BBB dysfunctions in various neurological disorders including neonatal HI brain injury. In the present review, we summarize the current findings regarding the role of miRNAs in BBB impairment after hypoxia/ischemia brain injury. Specifically, we focus on the recent progress of miRNAs in the pathologies of neonatal HI brain injury. These findings can not only deepen our understanding of the role of miRNAs in BBB impairment in HI brain injury, but also provide insight into the development of new therapeutic strategies for preservation of BBB integrity under pathological conditions.