Tumor-infiltrating lymphocytes, particularly the balance between CD8+ T cells and CCR4+ regulatory T cells, affect the survival of patients with oral squamous cell carcinoma
Tumor-infiltrating lymphocytes, particularly the balance between CD8+ T cells and CCR4+ regulatory T cells, affect the survival of patients with oral squamous cell carcinoma
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DOI：
10.1016/j.tripleo.2009.12.015
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发表时间：
2010-05-01
期刊：
影响因子：
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通讯作者：
Hashimoto, Kenji
中科院分区：
文献类型：
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作者：
Watanabe, Yoshiko;Katou, Fuminori;Hashimoto, Kenji
Objective.本研究的目的是阐明口腔鳞状细胞癌（OSCC）中肿瘤浸润淋巴细胞（TIL）的预后意义;本研究分析了各种TIL相关参数。采用免疫组化法检测87例口腔鳞癌患者的TIL相关指标：巢CD 8（+）T细胞、间质CD 8（+）T细胞、CD 4（+）T细胞、总调节性T细胞（TcR）、CCR 4（+）TcR、巢CD 8（+）T细胞/CCR 4（+）TcR、间质CD 8（+）T细胞/CCR 4（+）Treg。在单变量分析中，以下参数与生存率降低相关：巢和间质CD 8（+）T细胞较少，间质CCR 4（+）T细胞较多，但总T细胞较少。巢和间质CD 8（+）T细胞/CCR 4（+）Treg比率低与生存率差相关。多因素分析显示，间质CD 8（+）T细胞/CCR 4（+）Treg比值是独立的预后因素。口腔鳞癌间质中的宿主免疫反应影响患者的生存。效应性T细胞和调节性T细胞之间的原位平衡是预测存活的最重要因素。(Oral《口腔外科医学》《口腔病理学》《口腔放射学》，2010年; 109：744-752）
Objective. The objective of this study was to clarify the prognostic significance of tumor-infiltrating lymphocytes (TILs) in oral squamous cell carcinoma (OSCC); the present study analyzed various TIL-related parameters.Study design. Immunohistochemistry was performed in 87 patients with OSCC for the following TIL-related parameters: nest-CD8(+) T cells, stromal CD8(+) T cells, CD4(+) T cells, total regulatory T cells (Tregs), CCR4(+) Tregs, ratio of nest CD8(+) T cells/CCR4(+) Tregs, and ratio of stromal CD8(+) T cells/CCR4(+) Tregs.Results. In univariate analyses, the following parameters were associated with decreased survival: few nest-and stromal CD8(+) T cells and more stromal CCR4(+) Tregs, but not total Tregs. Low ratios of nest and stromal CD8(+) T cell/CCR4(+) Treg were associated with worse survival. In multivariate analysis, the stromal CD8(+) T cell/CCR4(+) Treg ratio was an independent prognostic factor.Conclusion. Host immune responses in the stroma of OSCC affect the survival of the patients. The in situ balance between effector T cells and regulatory T cells is the most important factor predicting survival. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109: 744-752)